Results 61 to 70 of about 1,246,426 (217)

Machine-learning based prediction of appendicitis for patients presenting with acute abdominal pain at the emergency department

World Journal of Emergency Surgery
Background Acute abdominal pain (AAP) constitutes 5–10% of all emergency department (ED) visits, with appendicitis being a prevalent AAP etiology often necessitating surgical intervention.
Anoeska Schipper, Peter Belgers, Rory O’Connor, Kim Ellis Jie, Robin Dooijes, Joeran Sander Bosma, Steef Kurstjens, Ron Kusters, Bram van Ginneken, Matthieu Rutten   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Quantitative comparison of automated OCT and conventional FAF-based geographic atrophy measurements in the phase 3 OAKS/DERBY trials

Scientific Reports
With the approval of the first two substances for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD), a standardized monitoring of patients treated with complement inhibitors in clinical practice is needed ...
Julia Mai, Gregor S. Reiter, Sophie Riedl, Wolf-Dieter Vogl, Amir Sadeghipour, Emma Foos, Alex McKeown, Hrvoje Bogunovic, Ursula Schmidt-Erfurth   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Lumbar spine segmentation in MR images: a dataset and a public benchmark

Scientific Data
This paper presents a large publicly available multi-center lumbar spine magnetic resonance imaging (MRI) dataset with reference segmentations of vertebrae, intervertebral discs (IVDs), and spinal canal.
Jasper W. van der Graaf, Miranda L. van Hooff, Constantinus F. M. Buckens, Matthieu Rutten, Job L. C. van Susante, Robert Jan Kroeze, Marinus de Kleuver, Bram van Ginneken, Nikolas Lessmann   +8 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Automated fluid monitoring to optimize the follow-up of neovascular age-related macular degeneration patients in the Brazilian population

International Journal of Retina and Vitreous
Objectives To investigate the efficacy of an artificial intelligence (AI)-based fluid monitoring tool in optimizing the monitoring of neovascular age-related macular degeneration (nAMD) patients in a Brazilian cohort. Methods This is a retrospective real-
Virginia Mares, Gregor S. Reiter, Aniel Feitosa, Markus Gumpinger, Hrvoje Bogunovic, Ursula Schmidt-Erfurth, Marcio B. Nehemy   +6 more
doaj   +1 more source

Denoising diffusion probabilistic models for addressing data limitations in chest X-ray classification

Informatics in Medicine Unlocked
Deep learning plays a crucial role in medical imaging analysis, particularly in tasks such as image classification and segmentation. However, learning from medical imaging datasets presents challenges, including scarcity of labeled examples, class ...
Evi M.C. Huijben, Josien P.W. Pluim, Maureen A.J.M. van Eijnatten   +2 more
doaj   +1 more source