Results 251 to 260 of about 492,068 (301)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Medical image processing on the GPU – Past, present and future

Medical Image Analysis, 2013
Graphics processing units (GPUs) are used today in a wide range of applications, mainly because they can dramatically accelerate parallel computing, are affordable and energy efficient.
Anders Eklund, Daniel Forsberg, Stephen M Laconte   +2 more
exaly   +3 more sources

Techniques of medical image processing and analysis accelerated by high-performance computing: a systematic literature review

Journal of Real-Time Image Processing, 2017
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Techniques of medical image processing and analysis play a crucial role in many clinical scenarios, including in diagnosis and treatment planning. However, immense quantities of data and
CARLOS A S J Gulo, Antonio CARLOS Sementille, João Manuel R S Tavares   +2 more
exaly   +2 more sources

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Challenges of medical image processing

Computer Science - Research and Development, 2010
In todays health care, imaging plays an important role throughout the entire clinical process from diagnostics and treatment planning to surgical procedures and follow up studies. Since most imaging modalities have gone directly digital, with continually increasing resolution, medical image processing has to face the challenges arising from large data ...
Scholl, Ingrid (Prof. Dipl.-Inf.), Aach, Til, Deserno, Thomas M., Kuhlen, Torsten   +3 more
openaire   +1 more source