Results 61 to 70 of about 1,151,344 (286)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Isotropic non-white matter partial volume effects in constrained spherical deconvolution

Frontiers in Neuroinformatics, 2014
Diffusion-weighted (DW) magnetic resonance imaging (MRI) is a noninvasive imaging method, which can be used to investigate neural tracts in the white matter (WM) of the brain.
Timo eRoine, Ben eJeurissen, Daniele ePerrone, Jan eAelterman, Alexander eLeemans, Wilfried ePhilips, Jan eSijbers   +6 more
doaj   +1 more source

MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging -- design, implementation and application on the example of DCE-MRI

, 2019
Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in DCE MRI/CT, ADC calculations and IVIM modeling in diffusion-weighted MRI and Z-spectra analysis
Abdollahi, Amir, Debus, Charlotte, Floca, Ralf, Ingrisch, Michael, Kompan, Ina, Maier-Hein, Klaus, Nolden, Marco   +6 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Directional analysis of intensity changes for determining the existence of cyst in optical coherence tomography images

Scientific Reports, 2022
Diabetic retinopathy (DR) is an important cause of blindness in people with the long history of diabetes. DR is caused due to the damage to blood vessels in the retina.
Maryam Monemian, Hossein Rabbani
doaj   +1 more source

Image processing in medical ultrasound [PDF]

, 2011
This Ph.D project addresses image processing in medical ultrasound and seeks to achieve two major scientific goals: First to develop an understanding of the most significant factors influencing image quality in medical ultrasound, and secondly to use ...
Hemmsen, Martin Christian
core  

A Multi-Armed Bandit to Smartly Select a Training Set from Big Medical Data

, 2017
With the availability of big medical image data, the selection of an adequate training set is becoming more important to address the heterogeneity of different datasets. Simply including all the data does not only incur high processing costs but can even
A Martino Di, A Mayer, B Fischl, C Wachinger, D Bouneffouf, David C. Van Essen, DS Marcus, H Shimodaira, K Ellis, K Franke, K Marek, Katja Franke, MP Milham, N Japkowicz, RL Gollub, S Pan, S Valizadeh, WR Thompson, Y Zhu   +18 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

K Means Segmentation of Alzheimers Disease in PET scan datasets: An implementation

, 2013
The Positron Emission Tomography (PET) scan image requires expertise in the segmentation where clustering algorithm plays an important role in the automation process. The algorithm optimization is concluded based on the performance, quality and number of
D.L. Pham, K.-P. Wong, M.C. Su, O.J. Oyelade   +3 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source