Results 141 to 150 of about 170,175 (308)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Multidimensional image analysis of cardiac function in MRI [PDF]

, 2006
Cardiac morphology is a key indicator of cardiac health. Important metrics that are currently in clinical use are left-ventricle cardiac ejection fraction, cardiac muscle (myocardium) mass, myocardium thickness and myocardium thickening over the cardiac ...
Lynch, Michael
core  

Methods of medical image segmentation analysis to improve the effectiveness of diagnosing lung diseases [PDF]

Methods of medical image segmentation analysis to improve the effectiveness of diagnosing lung diseases. The article aims to review selected methods for segmenting lung medical images based on computed tomography (CT) image data analysis. Included in the
Amelia Kosior-Romanowska, Piotr Bednarczuk, Zbigniew Orzeł   +2 more
core   +1 more source

Segment anything model for medical images?

Medical Image Analysis
Accepted by Medical Image Analysis.
Yuhao Huang 0001, Xin Yang 0009, Lian Liu, Han Zhou, Ao Chang, Xinrui Zhou, Rusi Chen, Junxuan Yu, Jiongquan Chen, Chaoyu Chen, Sijing Liu, Haozhe Chi, Xindi Hu, Kejuan Yue, Lei Li 0020, Vicente Grau, Deng-Ping Fan, Fajin Dong, Dong Ni 0001   +18 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

MedScale-Former: Self-guided multiscale transformer for medical image segmentation [PDF]

Accurate medical image segmentation is crucial for enabling automated clinical decision procedures. However, existing supervised deep learning methods for medical image segmentation face significant challenges due to their reliance on extensive labeled ...
Azad, Reza Khoshrooz, Merhof, Dorit, Karimijafarbigloo, Sanaz, Kazerouni, Amirhossein   +3 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Black-Box Adaptation for Medical Image Segmentation

Accepted early at MICCAI ...
Jay N. Paranjape, Shameema Sikder, S. Swaroop Vedula, Vishal M. Patel   +3 more
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source