Results 91 to 100 of about 2,954,647 (288)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

P396: DYSREGULATED DNAM-1 AND KIR2DL1 EXPRESSION IN NATURAL KILLER CELLS CORRELATES WITH POOR OUTCOME IN ACUTE MYELOID LEUKEMIA

HemaSphere, 2022
A. F O Costa, L. O Marani, I. A Lopes, L. S Binelli, P. S Scheucher, J. L S Schiavinato, M. I. A Madeira, K. B B Pagnano, B. K Duarte, A. B. F Glória, E. M Rego, F. Traina, R. Welner, L. L Figueiredo-Pontes   +13 more
doaj   +1 more source

Membrane Computing for Real Medical Image Segmentation

ARO-The Scientific Journal of Koya University, 2018
In this paper, membrane-based computing image segmentation, both region-based and edge-based, is proposed for medical images that involve two types of neighborhood relations between pixels. These neighborhood relations—namely, 4-adjacency and 8-adjacency
Rafaa I. Yahya, Siti Mariyam Shamsuddin, Salah I. Yahya, Bisan Alsalibi, Ghada K. Al-Khafaji   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

NFRs in Medical Imaging

CoRR
The diagnostic imaging departments are under great pressure due to a growing workload. The number of required scans is growing and there is a shortage of qualified labor. AI solutions for medical imaging applications have shown great potential. However, very few diagnostic imaging models have been approved for hospital use and even fewer are being ...
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

LUneXt: Simple and Efficient U-shaped Network Design for Medical Image Segmentation with Nonlinear Activation

Computing Open
Medical image segmentation has always been a challenging task. This paper proposes a new LUneXt medical image segmentation model based on the characteristics analysis of medical image data sets and testing of different nonlinear activation units.
Guanghong Deng, Bing Yu, Wenlong Jing, Yong Li, Xiaodan Zhao   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Improving Computer-Aided Medical Diagnosis Using Generative Adversarial Networks for Carotid Artery Ultrasound Image Data Augmentation and Classification

Journal of Electrical Engineering and Computer
Cardiovascular diseases are a leading cause of death globally, making early detection of atherosclerosis critical for prevention. Carotid artery ultrasound imaging is a common diagnostic tool; however, the limited availability of labelled medical images ...
Ricardo Fitas, João Gonçalves
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source