Results 231 to 240 of about 340,359 (301)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Identification of novel genes regulating the development of the palate

Developmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

The outcomes of electronic personal health records in patients with heart failure or coronary artery disease

ESC Heart Failure, Volume 12, Issue 2, Page 1464-1468, April 2025.
Abstract Background There are limited data on the efficacy of smartphone‐based personal health records (PHRs) in patients with cardiovascular disease. This study aimed to examine the processes, outcomes and challenges associated with the implementation of integrated PHRs in patients with heart failure (HF) or coronary artery disease (CAD). Methods This
Kotaro Nochioka, Satoshi Yasuda, Takashi Shiroto, Saori Yamamoto, Haruka Sato, Yuhi Hasebe, Shigeo Godo, Makoto Nakano, Tomohiko Shindo, Kensuke Nishimiya, Kiyotaka Hao, Jun Takahashi, Keisuke Ido, Yoichi Kakuta, Hiroaki Shimizu, Hiroaki Shimokawa, Masaharu Nakayama   +16 more
wiley   +1 more source

eGFR slope as predictor of mortality in heart failure patients

ESC Heart Failure, Volume 12, Issue 2, Page 1217-1226, April 2025.
Abstract Aims Heart failure (HF) leads to an imbalance between heart and kidney function, resulting in poor outcomes. However, the prognostic significance of the estimated glomerular filtration rate (eGFR) trajectory in HF patients remains unclear. We analysed electronic health records (EHRs) of real‐world HF patients, assessing eGFR trajectories and ...
Sofie Verstreken, Monika Beles, Clara L. Oeste, Ana Moya, Imke Masuy, Riet Dierckx, Ward Heggermont, Jeroen Dauw, Dries Hens, Jozef Bartunek, Marc Vanderheyden   +10 more
wiley   +1 more source

Evaluating and Enhancing the Fitness-for-Purpose of Electronic Health Record Data: Qualitative Study on Current Practices and Pathway to an Automated Approach Within the Medical Informatics for Research and Care in University Medicine Consortium. [PDF]

JMIR Med Inform
Kamdje Wabo G, Moorthy P, Siegel F, Seuchter SA, Ganslandt T.   +4 more
europepmc   +1 more source

Can epilepsy be predicted after the first febrile seizure? Insights from machine learning of postictal EEG

Epileptic Disorders, EarlyView.
Abstract Objective Febrile seizures (FS) are the most common seizures in childhood, yet identifying children at risk of developing epilepsy after the first FS remains challenging. We aimed to evaluate the prognostic potential of machine learning (ML) algorithms applied to post‐febrile seizure electroencephalography (EEG) recordings.
Boran Şekeroğlu, Hüseyin Öztoprak, Özlem Yayıcı Köken, Hatice Demir, Mehpare Sarı Yanartaş, Deniz Yılmaz, Burçin Şanlıdağ, Ayşegül Neşe Çıtak Kurt   +7 more
wiley   +1 more source

Epilepsy in emerging adulthood: Clinical, psychosocial, and surgical challenges

Epilepsia, EarlyView.
Abstract Objective Emerging adulthood (EAs; ages 19–29 years) is a unique developmental stage marked by major psychological, social, and occupational transitions. We sought to characterize the clinical, psychosocial, and surgical features of epilepsy in emerging adulthood, considering both current age and age at epilepsy onset.
Graham A. McLeod, Colin B. Josephson, Samuel Wiebe, The Calgary Comprehensive Epilepsy Program Collaborators, Felippe Borlot, Guillermo Delgado‐García, Paolo Federico, Nathalie Jette, Karl Martin Klein, William Murphy, Neelan Pillay, Andrea Salmon, Shaily Singh, The Epilepsy Surgery Satisfaction Questionnaire Study Group, Mark J. Atkinson, Walter J. Hader, Mark R. Keezer, Oluwaseyi A. Lawal, Sophia Macrodimitris, Kristina Malmgren, Dang K. Nguyen, Scott B. Patten, Tolulope T. Sajobi, Ruby Sharma, Yves Starreveld, José Tellez‐Zenteno, Sandra Wahby   +26 more
wiley   +1 more source

Systematic statistical analysis of change in SEIzure interVAL with diazepam nasal spray supports this novel clinical endpoint for immediate‐use seizure medication

Epilepsia, EarlyView.
Abstract Objective Appropriate endpoints for daily antiseizure medications may differ from those for intermittent, immediate‐use seizure medications (ISMs). The observed interval between seizure clusters over time (SEIzure interVAL [SEIVAL]) has been proposed as a novel effectiveness endpoint for ISMs.
Wesley T. Kerr, Katherine N. McFarlane, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +4 more
wiley   +1 more source

Pediatric sensorimotor cortical responsiveness to intracerebral stimulation during stereoelectroencephalographic monitoring: Age effects and area specificity

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to determine how age influences clinical responsiveness to intracerebral electrical stimulation (IES) in children across primary and secondary sensorimotor cortices and to assess age effects on response complexity and area‐specific responsiveness.
Giulia Nobile, Laura Tassi, Marta Ponzano, Piergiorgio d'Orio, Alessandro Consales, Luca Bosisio, Stefano Francione, Gabriele Arnulfo, Maria Pia Sormani, Lino Nobili, Roberto Mai   +10 more
wiley   +1 more source

High‐frequency oscillations after acute hemorrhagic traumatic brain injury: insights into posttraumatic epilepsy development

Epilepsia, EarlyView.
Abstract Objective The development of posttraumatic epilepsy after traumatic brain injury (TBI) is potentially identifiable by measuring biomarkers of epileptogenesis, namely pathological high‐frequency oscillations (pHFOs). pHFOs are promising candidates, but it remains uncertain whether they can be detected early after TBI in clinical settings.
Kseniia Kriukova, Lin Li, Richard J. Staba, Misque Boswell, Tuba Asifriyaz, Rachel Thomas, James J. Gugger, Mohamad Shamas, Ramon Diaz‐Arrastia, Manuel Buitrago Blanco, Jerome Engel, Paul M. Vespa, Dominique Duncan, on behalf of the EpiBios4Rx investigators, Denes Agoston, Alicia K. Au, Michael Bell, Ben Churn, Jan Claassen, Ramon Diaz‐Arrastia, Jerome Engel, Brandon Foreman, Aristea Galanopoulou, Emily Gilmore, Martin Hunn, Nathalie Jette, Andrew Morokoff, Solomon L. Moshé, Terence O'Brien, Joshua Laing, Piero Perucca, Kristine H. O'Phelan, Asla Pitkanen, Eric Rosenthal, Frederick Willyerd, Lara Zimmermann, Ben Ellingson, Buitrago Blanco, Daniel Correa, Dana Harrar, Thomas P. Bleck, Brian Appavu, Aaron Struck, Baxter Allen, Inna Keselman, Jeff Kennedy, Victor Ferastraoaru, Ji Yeoun Yoo, Arthur W. Toga   +48 more
wiley   +1 more source