Results 271 to 280 of about 4,691,719 (361)

In vivo intratumoral heterogeneity in a dish: scalable forebrain organoid models of embryonal brain tumors for high‐throughput personalized drug discovery

open access: yes
Cancer Communications, EarlyView.
Nicole C. Riedel   +21 more
wiley   +1 more source

Real‐World Effectiveness and Safety of Recombinant Human Follicle‐Stimulating Hormone (rhFSH) in Infertile Women undergoing Assisted Reproductive Technology (ART): A Korean Nationwide Cohort Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Despite widespread rhFSH use in infertile women undergoing ART, real‐world comparative data on its effectiveness and safety across different rhFSH types remain limited. Using the HIRA claims database, we included 10,684 women aged 20–39 with infertility (2016–2021) who used only rhFSH in their first in vitro fertilization–embryo transfer (IVF‐ET ...
Joong Yeup Lee   +12 more
wiley   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart   +6 more
wiley   +1 more source

Identification of neural crest and melanoma cancer cell invasion and migration genes using high‐throughput screening and deep attention networks

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Cell migration and invasion are well‐coordinated in development and disease but remain poorly understood. We previously showed that the neural crest (NC) cell migratory wavefront shares a 45‐gene panel with other cell invasion phenomena.
J. C. Kasemeier‐Kulesa   +3 more
wiley   +1 more source

A Pipeline for the Usage of the Core Data Set of the Medical Informatics Initiative for Process Mining – A Technical Case Report

open access: green
Hauke Heidemeyer   +9 more
openalex   +1 more source

Identification of novel genes regulating the development of the palate

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

Parallel Increase in Childhood Anorexia Nervosa and Early Puberty During the COVID‐19 Pandemic

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective During the COVID‐19 pandemic, an increase in anorexia nervosa (AN), specifically childhood AN, as well as in central precocious puberty (CPP) and early‐onset puberty (EOP), was reported. The aim of this study was to explore whether there was a population‐level association between increases in both disorders and to discuss possible ...
Beate Herpertz‐Dahlmann   +4 more
wiley   +1 more source

Weight Trajectories During Inpatient Treatment for Anorexia Nervosa: A Dynamic Time Warp Analysis

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Background Restoring weight is a primary goal during anorexia nervosa (AN) treatment. Previous studies linked different weight gain profiles to treatment outcomes, but there is currently no consensus on profile shapes and numbers. We argue that heterogeneity stems from temporal distortions (“warping”) in weight gain, and that similar weight ...
Marianne Tokic   +5 more
wiley   +1 more source

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