Results 271 to 280 of about 560,065 (339)
The role of intra‐abdominal pressure and point of care ultrasound to guide decongestive therapies in acute heart failure
ESC Heart Failure, EarlyView.The ABDOPOCUS‐HF trial is a randomized, single‐blind, low‐intervention clinical trial (n = 168) investigating the utility of intra‐abdominal pressure (IAP) and point of care ultrasound to guide decongestive therapies during the first 72 hours after admission for acute heart failure.C. Josa‐Laorden, A. Campos‐Saenz de Santamaría, S. Crespo‐Aznarez, J. Pérez‐Silvestre, E. Montero‐Hernandez, P. Llacer‐Iborra, J. Torres‐Macho, M. Méndez‐Bailon, J.L. Morales‐Rull, P. Salamanca‐Bautista, N. Fernández‐Villa, I. Torres‐Courchoud, M.A. Vázquez‐Ronda, R. Martínez‐Gutiérrez, P. Serrano‐Irigoyen, N. García‐Lorente, J.C. Trullas, M. Cobo‐Marcos, M.J. Pinilla, M. Sánchez‐Marteles, J. Rubio‐Gracia +20 morewiley +1 more sourceFerric carboxymaltose assessment of morbidity and mortality in patients with iron deficiency and chronic heart failure (FAIR‐HF2‐DZHK05) trial: Baseline characteristics and comparison to other relevant clinical trials
European Journal of Heart Failure, EarlyView.Differences in baseline characteristics between major trials of intravenous (IV) iron therapy in heart failure. LVEF, left ventricular ejection fraction; SGLT2, sodium–glucose cotransporter 2. Aims
Prior randomized trials have reported conflicting evidence regarding the efficacy of intravenous (IV) iron in patients with heart failure with reduced ...Stefan D. Anker, Tim Friede, Javed Butler, Khawaja M. Talha, Marius Placzek, Monika Diek, Anna Nosko, Adriane Stas, Stefan Kluge, Dominik Jarczak, Geraldine Deheer, Meike Rybczynski, Antoni Bayes‐Genis, Frank Edelmann, Gerasimos Filippatos, Gerd Hasenfuß, Wilhelm Haverkamp, Mitja Lainscak, Ulf Landmesser, Iain C. Macdougall, Bela Merkely, Burkert M. Pieske, Fausto J. Pinto, Tienush Rassaf, Maurizio Volterrani, Stephan von Haehling, Markus S. Anker, Wolfram Doehner, Hüseyin Ince, Friedrich Koehler, Gianluigi Savarese, Ursula Rauch‐Kröhnert, Tommaso Gori, Teresa Trenkwalder, Ibrahim Akin, Christina Paitazoglou, Iwona Kobielusz‐Gembala, Witold Zmuda, Luca Kuthi, Norbert Frey, Manuela Licka, Stefan Kääb, Karl‐Ludwig Laugwitz, Piotr Ponikowski, Mahir Karakas +44 morewiley +1 more sourceIntravenous ferric carboxymaltose in heart failure with iron deficiency (FAIR‐HF2 DZHK05 trial): Sex‐specific outcomes
European Journal of Heart Failure, EarlyView.Abstract Aims
Intravenous iron has emerged as a guideline‐recommended therapy in patients with heart failure and iron deficiency, but the potential sex‐related differences in efficacy are unknown. We aimed to assess sex‐specific outcomes in the Intravenous Iron in Patients with Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality Mahir Karakas, Tim Friede, Javed Butler, Khawaja M. Talha, Marius Placzek, Thomas Asendorf, Monika Diek, Anna Nosko, Adriane Stas, Stefan Kluge, Dominik Jarczak, Geraldine DeHeer, Meike Rybczynski, Antoni Bayes‐Genis, Michael Böhm, Andrew J.S. Coats, Frank Edelmann, Gerasimos Filippatos, Gerd Hasenfuß, Wilhelm Haverkamp, Mitja Lainscak, Ulf Landmesser, Iain C. Macdougall, Bela Merkely, Burkert M. Pieske, Fausto J Pinto, Tienush Rassaf, Jennifer K. Visser‐Rogers, Giuseppe Rosano, Maurizio Volterrani, Stephan von Haehling, Markus S. Anker, Wolfram Doehner, Hüseyin Ince, Friedrich Koehler, Gianluigi Savarese, Muhammad Shahzeb Khan, Ursula Rauch Kröhnert, Tommaso Gori, Teresa Trenkwalder, Ibrahim Akin, Christina Paitazoglou, Iwona Kobielusz‐Gembala, Luca Kuthi, Norbert Frey, Manuela Licka, Stefan Kääb, Karl‐Ludwig Laugwitz, Piotr Ponikowski, Stefan D. Anker +49 morewiley +1 more sourceClustering in dilated cardiomyopathy at initial evaluation: An effective tool for clinical stratification
European Journal of Heart Failure, EarlyView.Visual description of study design and main results. BBB, bundle branch block; ECG, electrocardiogram; MVA, major ventricular arrhythmia; SCD, sudden cardiac death. Abstract Aims
Dilated cardiomyopathy (DCM) has a highly variable presentation and disease course. Current stratification strategies are complex and require multimodality evaluation.Ilaria Gandin, Maria Perotto, Alessia Paldino, Giovanni Baj, Denise Zaffalon, Andrea Pezzato, Cinzia Crescenzi, Fabiana Romeo, Annamaria Martino, Francesca Fanisio, Federica Toto, Maddalena Rossi, Marta Gigli, Matteo Dal Ferro, Leonardo Calò, Gianfranco Sinagra, Marco Merlo +16 morewiley +1 more sourceSeverity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)
Environmental and Molecular Mutagenesis, EarlyView.Abstract
Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White +17 morewiley +1 more source
