Results 171 to 180 of about 927,466 (307)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Not lost in translation: Protocols for interpreting trauma-focused CBT [PDF]

, 2007
d'Ardenne, P, Farmer, E, Priebe, S, Ruaro, L   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Longitudinal Study on the Self-Reported Confidence of Medicine Interns Regarding Interpreting Chest Radiographs and Electrocardiograms, Performing Procedures, and Communicating With Patients' Families. [PDF]

Cureus
Dubey S, Roland M, Beekman K.
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Implementing interpreter training for dementia assessments at national scale using the RE-AIM framework: a mixed-methods evaluation. [PDF]

BMC Geriatr
Brijnath B, Clarke N, Markusevska S, Garcia EG, Hlavac J, Low LF, Woodward-Kron R, Antoniades J, Enticott J, Gilbert AS, LoGiudice D, Lin X, Hwang K, White J, Cavuoto M.   +14 more
europepmc   +1 more source

Assessing the capabilities of AI-based large language models (AI-LLMs) in interpreting histopathological slides and scientific figures: Performance evaluation study. [PDF]

Biomedicine (Taipei)
Gumilar KE, Ariani G, Wiratama PA, Rimbun, Yuliawati TH, Chen H, Ibrahim IH, Lin CH, Hung TY, Anggrahini D, Rajanagara AS, Omran KE, Yu ZY, Hsu YC, Dachlan EG, Yang JY, Liao LN, Tan M.   +17 more
europepmc   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Internal Disagreement and Conscience: A Catholic Context-Response to Brummett et al. [PDF]

Linacre Q
Bird J.
europepmc   +1 more source