Results 51 to 60 of about 119 (118)

Implementation of mass pharmacogenetic testing: Dihydropyrimidine dehydrogenase testing prior to fluoropyrimidine treatment for patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Pharmacogenomics enables personalization of drug therapy improving effectiveness and/or safety. Dihydropyrimidine dehydrogenase [DPYD] testing prior to fluoropyrimidine chemotherapy was commissioned by NHS England in response to an update from the Medicines and Healthcare products Regulatory Agency.
Nisha Shaunak, Jessica Keen, Anna Kim, Munir Pirmohamed, William G. Newman, Paul J. Ross   +5 more
wiley   +1 more source

Economic Rationality and International Humanitarianism: Ryōkichi Sagane's Advocacy Regarding the Introduction of Foreign Nuclear Reactors to Japan**

Berichte zur Wissenschaftsgeschichte, EarlyView.
Abstract The 2011 Fukushima Daiichi Nuclear Power Plant accident underscored the crucial role of nuclear engineering experts. However, the specific arguments and motivations of scientists advocating for the introduction of foreign reactors remain unclear.
Masahiro Inohana
wiley   +1 more source

Bringing Small Devices, Giving Design Advice: Introducing Radiation Protection Practices in Greece via the IAEA's Visiting Professor Program**

Berichte zur Wissenschaftsgeschichte, EarlyView.
Abstract This paper examines how an International Atomic Energy Agency (IAEA) expert mission for technical assistance in the late 1950s to Greece was effectively transformed into a mission to achieve the IAEA′s central objective: to consolidate its position as the leading global authority on radiation protection. The study focuses on the work of Alfred
Loukas Freris
wiley   +1 more source

Evaluating the effectiveness of virtual laboratory simulations for graduate‐level training in genetic methodologies

Biochemistry and Molecular Biology Education, EarlyView.
Abstract Virtual Labs (vLabs) have been gaining popularity in high school and undergraduate education, but there are few studies looking at their use in graduate‐level courses. In this study, we investigated the use of six Labster vLabs assigned as homework in a graduate‐level in‐person Genomic Methodologies course at the University of Toronto.
Johanna S. Carroll, Hedieh Najafi, Martina Steiner   +2 more
wiley   +1 more source

3D‐cultured BMSC exosomes improve cerebral ischemia/reperfusion injury‐induced neuronal apoptosis by regulating the microglia polarization

BMEMat, EarlyView.
The study reveals that microglial activation significantly contributes to neuroinflammation following cerebral ischemia‐reperfusion injury. It demonstrates that utilizing GelMA hydrogel for three‐dimensional culture of bone marrow‐derived mesenchymal stem cells (BMSCs) enhances the efficacy of BMSC‐derived exosomes in regulating microglial polarization
Yuming Li, Hao Shang, Qiong Zhang, Xianyong Yin, Zihao Liu, Yuqing Fang, Kyubae Lee, Huayang Zhao, Zhihai Wang, Hongbo Zhao, Xiaofeng Wang, Shengjie Li, Shan Wang, Tao Xin   +13 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy ...
Erwin A. van Vliet, Michael S. Hildebrand, James D. Mills, Gary P. Brennan, Tore Eid, Susan A. Masino, Vicky Whittemore, Laura Bindila, Kevin K. Wang, Manisha Patel, Piero Perucca, Christopher A. Reid   +11 more
wiley   +1 more source

Lead‐free transparent nanocomposite for efficient clinical X‐ray shielding

BMEMat, EarlyView.
A lead‐free nanocomposite of LaF3 nanoparticles exhibits a high optical transparency of 86% with a heavy loading of up to 70 wt%, which enables the design of radiation shielding goggles for interventional surgeons in real clinical scenarios. Abstract The increasing use of X‐ray imaging in the medical field has generated a growing need for efficient ...
Xiangzhou Zhang, Yeqi Liu, Xiaojia Wang, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Liang‐Jin Xu, Yaxing Wang, Zhaolai Chen, Yuhai Zhang   +8 more
wiley   +1 more source

Digital Technologies: Description, Classification, and Links to Circular Economy

Business Strategy and the Environment, EarlyView.
ABSTRACT Digital technologies (DTs) and circular economy (CE) are currently two topics that are expected to contribute significantly to sustainable development, and digitization is generally considered a key enabler of CE. However, most studies only cover the most known Industry 4.0 technologies, and very limited research detailing how DTs can support ...
Laura Piedra‐Muñoz, Eva M. García‐Granero, Raphael Ricardo Zepon Tarpani, Alejandro Gallego‐Schmid   +3 more
wiley   +1 more source

An open‐label, single‐arm, multicenter, phase II trial of bireociclib as monotherapy for heavily pretreated HR‐positive, HER2‐negative advanced breast cancer patients: BRIGHT‐1 trial

Cancer Communications, EarlyView.
Abstract Background Bireociclib (XZP‐3287) is a novel selective cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor, with a favorable safety profile demonstrated in preclinical and phase I studies. BRIGHT‐1 aimed to further explore the efficacy and safety of bireociclib monotherapy in patients with locally advanced, recurrent or metastatic, hormone ...
Jiayu Wang, Qingyuan Zhang, Tao Sun, Huiping Li, Ying Cheng, Zhongsheng Tong, Huihui Li, Wei Li, Jingfen Wang, Yuee Teng, Xinhong Wu, Jing Cheng, Zhendong Chen, Zhengqiu Zhu, Li Wang, Mingming Liu, Xianghui Duan, Lingmei Xu, Binghe Xu   +18 more
wiley   +1 more source