Results 161 to 170 of about 1,319,273 (307)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

1998 Annual Survey of Medical Laboratory Science Programs [PDF]

open access: yesLaboratory Medicine, 1999
Kory Ward-Cook   +2 more
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Immuno-Hematological and Biochemical Changes in Patients with Tuberculosis in Dessie Comprehensive Specialized Hospital, Dessie, Ethiopia

open access: yesJournal of Blood Medicine
Angesom Gebreweld,1 Temesgen Fiseha,2 Edosa Kebede,3 Zemenu Tamir,4 Brhane Gebremariam,5 Fikadu Miruts,1 Haftay Haileslasie1 1Department of Medical Laboratory Sciences, College of Health Science, Mekelle University, Mekelle, Ethiopia; 2Department of ...
Gebreweld A   +6 more
doaj  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

ASCP Board of Certification Survey of Medical Laboratory Science Faculty [PDF]

open access: yesLaboratory Medicine, 2019
Karen, Brown   +8 more
openaire   +2 more sources

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