Results 131 to 140 of about 5,869,961 (387)

AGMB-Arbeitskreis österreichischer Medizinbibliothekarinnen und -bibliothekare (AGMB.AT): Bericht vom 8. Treffen 2018 und vom 9. Treffen 2019

open access: yesGMS Medizin – Bibliothek – Information, 2019
The work group Austrian Medical Librarians (AGMB.AT) is a platform for the exchange of information and experience amongst medical librarians. On Dec 12, 2018 the 8 meeting took place at the Medical University Vienna.
Bauer, Bruno   +2 more
doaj   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls   +9 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

MiMICRI: Towards Domain-centered Counterfactual Explanations of Cardiovascular Image Classification Models [PDF]

open access: yes
The recent prevalence of publicly accessible, large medical imaging datasets has led to a proliferation of artificial intelligence (AI) models for cardiovascular image classification and analysis. At the same time, the potentially significant impacts of these models have motivated the development of a range of explainable AI (XAI) methods that aim to ...
arxiv   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Tıp ve Sağlık Bilimleri Kütüphaneciliğinde Ulusal ve Uluslararası Dernek Oluşumları / Formation of National and International Associations of Medical and Health Sciences Libraries [PDF]

open access: yesBilgi Dünyası, 2007
Medical libraries play important roles in classifying, storing andproviding access to medical information. Medical libraries are in steady development ever since 1850’s. This study reviews the formation of associations among modern medical libraries, and
Güssün Güneş
doaj  

Rigor and reproducibility instruction in academic medical libraries. [PDF]

open access: yesJ Med Libr Assoc, 2022
LaPolla FWZ   +5 more
europepmc   +1 more source

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