Results 31 to 40 of about 242,025 (294)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Study of the Quality of Services of Libraries of Qom University of Medical Sciences from the Point of View of Students and Academic Members Based on LibQUAL Model

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Since academic libraries have a significant role in promoting educational and research purposes of universities, therefore, assessment of the quality of services provided based on the expectations and needs of users with ...
Zahra Abazari, Zohreh Mirhosseini, Abdolhossein Bakhtiari, Akbar Mohammadi Motlaq   +3 more
doaj  

16 years of “Medical Library Forum”. From Johannes Gutenberg to Open Journal Systems

Forum Bibliotek Medycznych
The article aims to summarise the activity of the “Medical Library Forum” (MLF) – an scholarly journal which has served to share ideas and record the work of medical university libraries and related institutions for over 16 years now.
Agnieszka Czarnecka, Krzysztof Włodarczyk   +1 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Academic Medical Library Services Contribute to Scholarship in Medical Faculty and Residents

Evidence Based Library and Information Practice, 2017
A Review of: Quesenberry, A. C., Oelschlegel, S., Earl, M., Leonard, K., & Vaughn, C. J. (2016). The impact of library resources and services on the scholarly activity of medical faculty and residents.
Peace Ossom Williamson
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Krankenhausbibliotheken, Pharmabibliotheken, veterinärmedizinische Bibliotheken / Hospital libraries, pharmaceutical libraries, veterinary medical libraries

GMS Medizin – Bibliothek – Information, 2011
The recent issue 1-2/2011 of GMS Medizin – Bibliothek – Information has a focus on hospital libraries, pharmaceutical libraries and veterinary medical libraries.
Bauer, Bruno
doaj  

AGMB-Wettbewerb „Leuchtturmprojekte an Medizinbibliotheken 2020“: Würdigung der Preisträger

GMS Medizin – Bibliothek – Information, 2020
The projects of the winners of the competition “Pioneer projects in medical libraries 2020” are introduced and the statement of the jury explained.
Reimann, Iris
doaj   +1 more source

Forschungsnahe Dienstleistungen in den Bibliotheken der Mitglieder der Arbeitsgemeinschaft Evidenzbasierte Medizin (AG-EBM) der AGMB

GMS Medizin – Bibliothek – Information, 2023
In Spring 2023 an online survey was realized among all medical librarian members of the working group on evidence-based medicine (AG-EBM) within the German Medical Library Association (AGMB). The focus of this survey was to characterize the services that
Cascant Ortolano, Lorena, Buroh, Sabine, von Gernler, Marc, Krause, Evamaria, Härkönen, Sonja, Ewald, Hannah   +5 more
doaj   +1 more source