Results 91 to 100 of about 929,810 (294)

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Advances in fungal vaccine development: Progress in the face of emerging challenges

iScience
Summary: Historically overshadowed by bacterial and viral infections, fungal diseases are resurging globally, fueled by rising antifungal resistance and the increasing vulnerability of immunocompromised populations in healthcare settings.
Munika Moses, Xinhua Huang, Xinying Xue, Changbin Chen   +3 more
doaj   +1 more source

Introduction to Medical Microbiology: A Hands-on Laboratory

MedEdPORTAL, 2013
Introduction While anatomy laboratory sessions remain a staple in the medical school curriculum, microbiology laboratories are often phased out for virtual labs or phased out completely.
Melphine Harriott
doaj   +1 more source

Seroprevalence Of Hepatitis-b Virus In Mid And Far Western Region In Nepal [PDF]

, 2012
Hepatitis B is significant health problems that might involve the late sequel of liver cirrhosis and hepatocellular carcinoma. The present study aimed to know the seroprevalence of hepatitis B virus (HBV) in mid and far western region in Nepal with ...
H, S. A. (Siddiqui), M, A. (Ansari), P, S. (Singh), S, K. (Khan)   +3 more
core  

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Liver abscess induced by intestinal hypervirulent Klebsiella pneumoniae through down-regulation of tryptophan-IPA-IL22 axis

iScience
Summary: Hypervirulent Klebsiella pneumoniae (hvKp) is a significant causative agent of invasive hepatic abscess syndrome in Asia, presenting substantial clinical challenges due to its intricate pathogenesis.
Xiu You, Liping Wang, Hong Wang, Yizheng Xu, Yongzheng Chen, Huizhen Xu, Xuelian Ji, Xiangsong Ma, Xiuyu Xu   +8 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Emerging bacterial factors for understanding pathogenesis of endometriosis

iScience
Summary: The pathogenesis of endometriosis is a complex process, and recent research has introduced novel hypotheses in this field. This review summarizes recent studies on the pathogenesis of endometriosis. We focused on several classical hypotheses, as
Ayako Muraoka, Akira Yokoi, Hiroaki Kajiyama   +2 more
doaj   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Evaluation of whole-genome enrichment and sequencing of T. pallidum from FFPE samples after 75 years

iScience
Summary: The recent developments in genomic sequencing have permitted the publication of many new complete genome sequences of Treponema pallidum pallidum, the bacterium responsible for syphilis, which has led to a new understanding of its phylogeny and ...
Vincent Zvenigorosky, Angéla Gonzalez, Gilles Veith, Tricia Close-Koenig, Catherine Cannet, Jean-Luc Fausser, Alexandre Wenger, Laurence Toutous-Trellu, Christine Keyser, Christian Bonah   +9 more
doaj   +1 more source