Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez+5 more
wiley +1 more source
Medical Oncology Group of Australia Annual Scientific Meeting, August 2-4, 2023. [PDF]
Caga-Meller J.
europepmc +1 more source
Higher training and continuing medical education in radiation oncology in the United Kingdom
Richard G.B. Evans
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Reply to the Letter to the Editor “Critical appraisal of the Minimal Clinical Recommendations (MCR) of the European Society for Medical Oncology (ESMO): challenges for a European framework for the development of clinical practice guidelines”,by B. Fervers, T. Philip andG. P. Browman (Ann Oncol 2002; 13: 1507–1509) [PDF]
Rolf A. Stahel
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ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee+9 more
wiley +1 more source
First impressions: A prospective evaluation of patient-physician concordance and satisfaction following the initial medical oncology consultation. [PDF]
Bach Y+20 more
europepmc +1 more source
Benefits of psychosocial oncology care: improved quality of life and medical cost offset. [PDF]
Linda E. Carlson, Barry D. Bultz
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Estudo descritivo, com abordagem quantitativa, que objetivou identificar o perfil dos profissionais de enfermagem de uma unidade de transplante de células-tronco hematopoiéticas e ações utilizadas para o cuidar de si. Para sustentação teórica utilizou-se
Sandra Hilda Sobrinho+2 more
doaj
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan+4 more
wiley +1 more source