Results 91 to 100 of about 23,211,796 (257)

Understanding the processes of Information Systems deployment and evaluation: The challenges facing e-health [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Information Systems (IS) innovations in healthcare sector are seen as panacea to control burgeoning demand on healthcare resources and lack of streamlining ...
Sharma, Urvashi
core   +4 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Adaptive questionnaires for facilitating patient data entry in clinical decision support systems: methods and application to STOPP/START v2

BMC Medical Informatics and Decision Making
Clinical decision support systems are software tools that help clinicians to make medical decisions. However, their acceptance by clinicians is usually rather low.
Jean-Baptiste Lamy, Abdelmalek Mouazer, Romain Léguillon, Romain Lelong, Stéfan Darmoni, Karima Sedki, Sophie Dubois, Hector Falcoff   +7 more
doaj   +1 more source

Journal of Information Technology Management A Publication of the Association of Management EXPLORING DIFFUSION OF COMPUTERIZED PHYSICIAN ORDER ENTRY (CPOE) SYSTEMS FOR IMPROVING PHYSICIANS' ROUTINE OPERATIONS IN HOSPITALS: AN EMPIRICAL SURVEY

, 2014
In our study, the adoption and implications of computerized physician order entry (CPOE) were investigated to answer the central research question, "What factors facilitate health care organizations receptivity to adopting and implementing CPOE ...
Entry, Exploring, Of, Physician Order
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Análisis de los problemas relacionados con los medicamentos en un hospital de tercer nivel de Barcelona

Gaceta Sanitaria, 2019
Resumen: Objetivo: Describir los problemas relacionados con la medicación detectados en pacientes ingresados y analizar el grado de aceptación de las recomendaciones propuestas.
Olivia Ferrández, Borja Casañ, Santiago Grau, Javier Louro, Esther Salas, Xavier Castells, Maria Sala   +6 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Theoretical Applicability of Different Occluder Systems for Entry Closure in Type B Aortic Dissection: An Image-Morphological Study

Biomedicines
Objective: Type B aortic dissection is a life-threatening medical condition. Endovascular closure of the primary entry by means of TEVAR is considered, nowadays, the gold standard if operative treatment is necessary.
Miroslav Yordanov, Alexander Oberhuber, Johannes Frederik Schäfers, Raman Anzz, Abdulhakim Ibrahim   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source