Results 221 to 230 of about 8,981,556 (292)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Author Correction: Membrane remodelling mediates lipopeptide-induced immunity in Arabidopsis. [PDF]

Nat Plants
Gilliard G, Pršić J, Crowet JM, Chemotti C, Ahmed J, Lorent J, Jolivet MD, Egli S, Egée S, Bouyer G, Race G, van Buren L, Van Den Berghe A, Argüelles-Arias A, Mathelié-Guinlet M, Ibrahim H, Genva M, Fouillen L, Mirande-Bret C, Razin O, Vue B, Župunski M, Luzuriaga-Loaiza WP, Deboever E, Nasir MN, Lins L, Van Der Smissen P, Boubsi F, Eschrig S, Germain V, Höfte M, Zipfel C, Dufrêne YF, Tyteca D, Koutsioubas A, Brocca P, Grossmann G, Ranf S, Dorey S, De Coninck B, Nürnberger T, Mongrand S, Gronnier J, Rondelli V, Deleu M, Ongena M.   +45 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Medicinal Plants as Biopesticides Against Pests and Diseases of Maize (<i>Zea mays</i> L.) in Africa: Ethnobotanical Insights and Challenges. [PDF]

Plants (Basel)
Aina FB, Buwa-Komoreng L, Heshula LUP, Mutengwa CS.   +3 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Online sources of health-related traditional knowledge: content for a traditional medicine library. [PDF]

Bull World Health Organ
Abdala CV, Schveitzer MC, Ghelman R, Puerta-Diaz M, Sousa MSA, Sattigeri VJ, Pillai GKG, Kajiwara M, Kuruvilla S, Souza JP.   +9 more
europepmc   +1 more source

The power of zinc: excess and deficiency of Zn decrease cannabinoids in cannabis without Zn toxicity concerns to consumers. [PDF]

J Cannabis Res
Shiponi S, Bernstein N.
europepmc   +1 more source

Changes of medicinal food plant uses in the Gaoligongshan biocultural diversity center, China. [PDF]

J Ethnobiol Ethnomed
Cheng Z, Lou X, Xu RA, Xia F, Long C.
europepmc   +1 more source

Virtual herbal garden (Hayushasutra): An educational aid for Ayurveda students. [PDF]

J Ayurveda Integr Med
Allam R, Kothainayagi B, Sudhir PA, Muralikumar VR, Arumugam M, Robin CRR, Yokesh S, Vishali U, Fahima S.   +8 more
europepmc   +1 more source

Non-specific phospholipase Cs and their potential for crop improvement. [PDF]

J Exp Bot
Yang B, Fan R, Yao S, Lou H, Li J, Guo L, Wang X.   +6 more
europepmc   +1 more source