Results 111 to 120 of about 2,671,946 (314)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Referee report. For: Sleep quality among undergraduate students of a medical college in Nepal during COVID-19 pandemic: an online survey [version 1; peer review: 1 approved]

, 2021
Roshan Acharya
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Guidelines for Standardization Work of Rehabilitation Medicine Association （2025 Edition）

康复学报
As an integral component of China's standardization system, rehabilitation medicine association standards play a pivotal role in regulating clinical practice, ensuring care quality, and nurturing rehabilitation professionals.
CHEN Hanbo, YAN Tiebin, SHI Xiu'e, WU Ming, CHEN Wenhua, WANG Yulong, WU Wei, DUAN Zhouying, LEI Lei, BI Sheng, LU Xiao, SONG Zhenhua, SUN Wenjing   +12 more
doaj  

Methodology of forming a model of diagnosis-related groups for cases of medical care using surgery performed by laparoscopic access

Фармакоэкономика
Background. A wide range of endosurgical treatment methods in various medical care profiles and the need for uniformity of calculations required developing a unified approach to the formation of diagnosis-related groups (DRGs) for cases of surgical ...
I. A. Zheleznyakova, O. A. Volkova, E. I. Rumiantseva, I. A. Mikhailov, D. V. Fedyaev, A. V. Zuev, O. S. Plakhotnik, G. V. Trifonova, T. S. Vakhrusheva, E. S. Samsonova, V. V. Omelyanovskiy   +10 more
doaj   +1 more source

EXPERIENCE OF ORGANIZATION THE PROCESS FOR MEDICAL CARE QUALITY CONTROL IN THE TERMS OF REGIONAL CONSULTATIVE POLICLINIC

, 2015
L. N. Sviderskaya, V. M. Simacova, V. T. Hendogina, Ф. П. Чавкунькин   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Analysis of factors influencing 3-and 6-h compliance with the surviving sepsis campaign guidelines based on medical-quality intensive care unit data from China. [PDF]

Chin Med J (Engl), 2021
Wang L, Ma XD, He HW, Su LX, Guo YH, Shan GL, Zhou X, Liu DW, Long Y, China National Critical Care Quality Control Center group.   +9 more
europepmc   +1 more source

Functional potential and applications of Ureibacillus massiliensis based on whole-genome sequencing analysis

BMC Microbiology
Background Ureibacillus massiliensis (U. massiliensis), a Gram-positive bacterium belonging to the phylum Bacillota, has undergone two significant taxonomic revisions before being classified under the Ureibacillus.
Shiyao He, Qi Ding, Wenting Wu, Yun Zhang, Yan Kang, Yang Meng, Sirui Zhu, Jinyuan Wu   +7 more
doaj   +1 more source