Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Comprehensive evaluation of medical quality and analysis of obstacle factors in specialized neurological hospitals based on a multi-dimensional evaluation model: a case study of China's National Regional Medical Center for Neurological Diseases. [PDF]
Liu Q.
europepmc +1 more source
Quality assurance in medical education
openaire +3 more sources
Daily Impact of Medical Cannabis on Anxiety and Sleep Quality in Older Adults
Madison Maynard +6 more
openalex +2 more sources
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Cohort profile: the Norwegian Neck and Back Registry (NNRR): a medical quality registry for patients with neck and back complaints. [PDF]
Aars NA +13 more
europepmc +1 more source
Improvements in medical quality and patient safety through implementation of a case bundle management strategy in a large outpatient blood collection center. [PDF]
Zhao S, He L, Feng C, He X.
europepmc +1 more source

