Results 241 to 250 of about 2,671,946 (314)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The theoretical impact of AI-based quality evaluation of short-video health information on public cognition and treatment adherence: a case study of denosumab combined with PD-1/PD-L1 therapy for lung cancer bone metastasis. [PDF]

Front Public Health
Wang JW, Xun JJ, Zhao FF.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Consistent explainable image quality assessment for medical imaging. [PDF]

Health Inf Sci Syst
Ozer C, Guler A, Turkvatan Cansever A, Oksuz I.   +3 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The use of large language models in generating multiple choice questions for health professions education: A systematic review and network meta-analysis. [PDF]

PLoS One
Riehm L, Nanji K, Lakhani M, Pankiv E, Hasanee D, Pfeifer W.   +5 more
europepmc   +1 more source

Clinical governance in radiation oncology. [PDF]

Rep Pract Oncol Radiother
Malicki J, Guedea F, Krengli M.
europepmc   +1 more source

Governance of Clinical Data Quality in Electronic Health Records: Administrative Policies, Health Informatics Systems, and Medical Secretarial Practices

Bader Abdulrahman Sulayman Almuballi, Muslih Quaymil Nughaymish Alshamlani, Yasir Abdullah Alghofaili, Faihan Hamdan Lattif Alshammari, Latifeh Matar Salem Alattwei, Abdullah Abdulrahman Alsaif, Amjad Mubarak Alansari, Orjwan Mansoor Thabet Alhazmi, Nouf Khalid Abualfaraj, Salma Omar Mandour   +9 more
openalex   +2 more sources

Early Impact of a Co-Designed Playgroup for Children With Medical Complexity: A Mixed Methods Pilot Study. [PDF]

J Patient Exp
Nizzer S, McKay SM, Wong M, Nichol K.
europepmc   +1 more source

The hidden cost of medical education: health anxiety and quality of life among Saudi medical students

terra, mohamed, baklola, mohamed, Al-bawah, Naji, Z. Alshahrani, Najim   +3 more
openalex   +1 more source