Results 191 to 200 of about 572,166 (310)

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Highlights from the first interdisciplinary summit of the European Association of Cardiovascular Imaging and the European Society for Cardiovascular Radiology. [PDF]

Eur Heart J Cardiovasc Imaging
Vliegenthart R, Baritussio A, Budde RPJ, Pontone G, van Assen M, Dacher JN, Danad I, Delgado V, Dweck MR, van der Harst P, Hirsch A, Huisman M, Kozerke S, Pezel T, Pugliese F, Westwood M, Williams MC, Paar MH, Manka R, Salgado R, Nijveldt R.   +20 more
europepmc   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Mind the gap: challenges and future directions for content-based image retrieval in clinical radiology. [PDF]

Front Radiol
Spada E, Erb-Eigner K, Pahud de Mortanges A, Reyes M, Pöllinger A.   +4 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Towards an accessible, centralised, searchable database for AI courses in Europe: the Artificial Intelligence in Medical Imaging and Radiation Oncology Education (AIMIROE) project. [PDF]

Eur Radiol Exp
Decoster R, Erenstein H, Menzinga J, Cornacchione P, Cunha A, Dybeli E, Mekis N, McEntee M, Paalimäki-Paakki K, Precht H, Akinci D'Antonoli T, Cuocolo R, Huisman M, Klontzas ME, Kotter E, Pinto Dos Santos D, Ranschaert E, van Ooijen P, Stogiannos N, Malamateniou C.   +19 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Assessing the Reliability, Accuracy, and Relevance of Artificial Intelligence Speech Recognition for Clinical Documentation: A Scoping Review. [PDF]

J Eval Clin Pract
Atiku S, Owolanke K, Olakotan O.
europepmc   +1 more source

Industrial and Medical Radiology [PDF]

Nature, 1920
openaire   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source