Results 111 to 120 of about 2,602,284 (275)
Frontiers in ImmunologyAcute myeloid leukemia (AML), originating from myeloid hematopoietic stem/progenitor cells, is a malignant hematological disorder. Resistance to current treatments, especially in FLT3-ITD AML cases, urgently demands the development of novel therapeutics.
Maoqiong Hu +3 more
doaj +1 more source
National Hospital Management Portal (NHMP): a framework for e-health implementation [PDF]
, 2010 Health information represents the main basis for health decisionmaking process and there have been some efforts to increase access to health information in developing countries.
Adetiba, E. +4 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Constructing a Basefile for Simulating Kunming’s Medical Insurance Scheme of Urban Employees [PDF]
Focusing on China’s medical insurance scheme which covers all employers and employees in urban areas, this research aims to assess the distributional impacts of medical insurance policies and to predict medical expenses by using microsimulation ...
Liu Hong, Tang Weidong, Xiong Linping
core
Summarisation and visualisation of e-Health data repositories [PDF]
, 2006 At the centre of the Clinical e-Science Framework (CLEF) project is a repository of well organised, detailed clinical histories, encoded as data that will be available for use in clinical care and in-silico medical experiments.
Hallett, Catalina +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Common laboratory parameters as predictors of prognosis in primary lung cancer
Frontiers in OncologyBackgroundThe prognosis of patients with primary lung cancer remains poor. Therefore, this study aimed to develop and validate a predictive model to evaluate the overall survival (OS) of these patients.MethodsA retrospective analysis was conducted on the
Mingchun Cai +3 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Frontiers in Public HealthBackgroundIn China, coronary heart disease (CHD) is a significant public health issue affecting the population's health. Evidence suggests that outdoor PM2.5 is a crucial environmental risk factor for CHD mortality.
Yuan Ma +6 more
doaj +1 more source