Results 181 to 190 of about 129,657 (301)

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Cancer registries in Pakistan: a scoping review. [PDF]

Lancet Reg Health Southeast Asia
Virani SS, Ahmed KS, Springer M, Hussain M, Christensen L, Asif F, Pervez S, Fadoo Z, Belgaumi A, Zafar SN.   +9 more
europepmc   +1 more source

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

Study for the validation of evaluation indicators of electronic health records in immunization: Delphi technique. [PDF]

Rev Bras Enferm
Fernandes CHP, Figueiredo MAA.
europepmc   +1 more source

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

Advanced Science, EarlyView.
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu, Jin‐Yin Huang, Xing‐Zhe Xu, Ji‐Yu Sun, Dan‐Ni Zou, Jia‐Yao Zhang, Chen Chi, Qi Zhang, Wei‐Cai Liu   +8 more
wiley   +1 more source

The effect of electronic prescription systems on pharmacy performance through evaluation of existing infrastructure in Kerman Iran. [PDF]

Sci Rep
Karimi S, Jahani Y, Ahmadian L.
europepmc   +1 more source

BrainFusion: a Low‐Code, Reproducible, and Deployable Software Framework for Multimodal Brain‒Computer Interface and Brain‒Body Interaction Research

Advanced Science, EarlyView.
BrainFusion is a low‐code software framework for multimodal brain–computer interface (BCI)​​ and brain–body interaction research. It supports ​electroencephalography (EEG)​, functional near‐infrared spectroscopy (fNIRS), electromyography (EMG)​, and electrocardiography (ECG)​​ integration with standardized preprocessing, feature fusion, and model ...
Wenhao Li, Chenyang Gao, Zhaobo Li, Yunheng Diao, Jiaxin Li, Jiayi Zhou, Jing Zhou, Ying Peng, Guanchu Chen, Xuecheng Wu, Kai Wu   +10 more
wiley   +1 more source

Mitigating Risks in Hospital Stock Management: A Structured Method for Validating Excel Files. [PDF]

Hosp Pharm
Gaoual Y, Aliat Z, Cherif Chefchaouni A, Mahyaoui A, Merhom O, Rahali Y.   +5 more
europepmc   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Identifying Asthma-Related Symptoms From Electronic Health Records Using a Hybrid Natural Language Processing Approach Within a Large Integrated Health Care System: Retrospective Study. [PDF]

JMIR AI
Xie F, Zeiger RS, Saparudin MM, Al-Salman S, Puttock E, Crawford W, Schatz M, Xu S, Vollmer WM, Chen W.   +9 more
europepmc   +1 more source