Results 191 to 200 of about 129,657 (301)

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Neonatal outcome in late preterm twin gestation: impact of antenatal corticosteroids therapy before 34 weeks. [PDF]

BMC Pregnancy Childbirth
Eliner O, Dicker-Sagy E, Schreiber H, Cohen G, Biron-Shental T, Kovo M.   +5 more
europepmc   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Strengths and weaknesses of computerized clinical decision support systems: insights from a digital control center (C3 COVID-19) for early and personalized treatment for COVID-19. [PDF]

Rev Esp Quimioter
Aiello TF, Teijon-Lumbreras C, Gallardo-Pizarro A, Monzó-Gallo P, Martinez-Urrea A, Cuervo G, Del Rio A, Hernández-Meneses M, Morata L, Mensa J, Soriano A, Garcia-Vidal C.   +11 more
europepmc   +1 more source

ε‐Poly‐L‐lysine‐graft‐oligo(3‐hexylthiophene) Copolymers as Antibacterial and Biodegradable Polymer Electronics

Advanced Science, EarlyView.
ε‐Poly‐L‐lysine‐graft‐oligo(3‐hexylthiophene) (EPL‐g‐O3HT) copolymers are engineered as biodegradable and antibacterial materials for transient electronics. EPL‐g‐O3HT exhibits tunable conductivity, controlled enzymatic degradability, good biocompatibility, and potent antibacterial activity. They are demonstrated in electromyography sensors and organic
Xin Sun, Eddie Wai Chi Chan, Fathumma Rizana Shiraz, Bicheng Zhu, Jingwen Yang, Katharina Matura, Viji Sarojini, Serpil Tekoglu, David Barker, Jadranka Travas‐Sejdic   +9 more
wiley   +1 more source

Data Interoperability and Harmonization in Cardiovascular Genomic and Precision Medicine. [PDF]

Circ Genom Precis Med
Chahal CAA, Alahdab F, Asatryan B, Addison D, Aung N, Chung MK, Denaxas S, Dunn J, Hall JL, Pamir N, Slotwiner DJ, Vargas JD, Armoundas AA.   +12 more
europepmc   +1 more source

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

Optimizing Clinical Decision Support System Functionality by Leveraging Specific Human-Computer Interaction Elements: Insights From a Systematic Review.

JMIR Hum Factors
Azadi A, García-Peñalvo FJ.
europepmc   +1 more source

Unveiling the Disparities in the Field of Precision Medicine: A Perspective. [PDF]

Health Sci Rep
Morsi MH, Elawfi B, ALsaad SA, Nazar A, Mostafa HA, Awwad SA, Abdelwahab MM, Tarakhan H, Baghagho E.   +8 more
europepmc   +1 more source

Toward the Clinical Translation of Implantable Brain–Computer Interfaces for Motor Impairment: Research Trends and Outcome Measures

Advanced Science, EarlyView.
Implantable brain–computer interfaces (iBCIs) are rapidly approaching clinical translation. This review maps key trends in the development of iBCIs and highlights the lack of standardised clinical outcome measures. It discusses a proposed framework for the selection of outcome measures in clinical trials and introduces a new international registry of ...
Esmee Dohle, Eleanor Swanson, Luka Jovanovic, Suraya Yusuf, Lucy Thompson, Hugo Layard Horsfall, William Muirhead, Luke Bashford, Jamie Brannigan   +8 more
wiley   +1 more source