Results 91 to 100 of about 16,847,686 (287)

An instrument to identify computerised primary care research networks, genetic and disease registries prepared to conduct linked research: TRANSFoRm International Research Readiness (TIRRE) survey

Journal of Innovation in Health Informatics, 2018
PURPOSE: The Translational Research and Patients safety in Europe (TRANSFoRm) project aims to integrate primary care with clinical research whilst improving patient safety. The TRANSFoRm International Research Readiness survey (TIRRE) aims to demonstrate
Emily Jennings, Simon de Lusignan, Georgios Michalakidis, Paul Krause, Frank Sullivan, Harshana Liyanage, Brendan Delaney   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Potential application of item-response theory to interpretation of medical codes in electronic patient records [PDF]

, 2011
Background: electronic patient records are generally coded using extensive sets of codes but the significance of the utilisation of individual codes may be unclear. Item response theory (IRT) models are used to characterise the psychometric properties of
Van Staa, Tjeerd; id_orcid, Little, P., Delaney, B., Delaney, Brendan, Wolfe, C., van Staa, Tjeerd, Gulliford Martin C, Grieve Andy, Gulliford, M.C., Charlton, Judith, Gulliford, Martin C., Little, Paul, Martin C Gulliford, Grieve, A., van Staa, T., Yardley, L., Dregan Alex, Dregan, A., Moore, M., Taweel, Adel, Andy Grieve, Moore, Michael, Charlton, J., Dregan, Alex; id_orcid, Taweel, A., Tjeerd van Staa, Dregan, Alex, Yardley, Lucy, van Staa Tjeerd, null null, Wolfe, Charles, Rudd, A., Gulliford, Martin C, Rudd, Anthony, eCRT Research Team, Grieve, Andy, Alex Dregan   +36 more
core   +2 more sources

Endoscopic electronic medical record systems [PDF]

Gastrointestinal Endoscopy, 2016
Michael A, Manfredi, Shailendra S, Chauhan, Brintha K, Enestvedt, Larissa L, Fujii-Lau, Vani, Konda, Joo Ha, Hwang, Simon K, Lo, John T, Maple, Faris M, Murad, Rahul, Pannala, Karen L, Woods, Subhas, Banerjee   +11 more
openaire   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Manifesto for medical research [PDF]

, 2015
The MRCG want to ensure there is a dynamic medical research environment in Ireland. Ensuring priority investment for medical research will help to deliver patient care, public health service transformation and economic and enterprise development.
Medical Research Charities Group
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Use of computerized clinical support systems in medical settings, United States, 2001-03 [PDF]

"OBJECTIVES: This report presents information on the use of electronic clinical systems to support patient care in physician offices and hospital emergency and outpatient settings.

core  

Medical audio recording content recording system for completing medical documentation

Reporter of the Priazovskyi State Technical University. Section: Technical sciences
У статті розглядається проблема ведення медичної документації лікарями, що є одним із найбільш трудомістких аспектів роботи лікаря в сучасній системі охорони здоров'я. Лікарі витрачають багато робочого часу на заповнення електронних медичних карток та іншої документації, що уповільнює та знижує якість медичної допомоги.
H.A. Zaturovskyi, H.A. Pidnebesna
openaire   +3 more sources