Results 91 to 100 of about 3,654,618 (260)

Data-Driven Computations in the Life Sciences [PDF]

, 2015
Mathematical modeling and simulations in the Life Sciences is a very ambitious and rapidly developing interdisciplinary research field that connects mathematics, computational sciences and engineering to biology and medicine.
Pires, Marília, Sequeira, Adélia, Tiago, Jorge   +2 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Phage-display法を用いたIgG型抗二十鎖DNA自己抗体のクローニングとその機能解析 [PDF]

, 2000
Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no. 2423, 2000.3.24Joint authors: Yoshihiro Katsube ... [et al.]Offprint. Originally published: International Journal of Molecular Medicine, v. 3, pp.
Suzuki Motohiro, 鈴木 基博
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Correction to: Evaluating the Lifelong Learning Approach to Demand-Oriented Research in Student Theses Using the ADDIE Model [PDF]

Journal of Mazandaran University of Medical Sciences
Abolghasem Rahmani1, Pooria Gill2, Siavash Moradi3, Atefeh Zabihi Zazoly4, Fattane Amuei5, Adele Rafati6 1 MSc in Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Science, Sari, Iran 2 Professor ...
Abolghasem Rahmani, Pooria Gill, Siavash Moradi, Atefeh Zabihi Zazoly, Fattane Amuei, Adele Rafati   +5 more
doaj  

Effects of hyperhomocysteinemia on follicular development and oocytes quality

iScience
Summary: In patients with polycystic ovary syndrome (PCOS), the concentration of homocysteine (Hcy) in follicular fluid is inversely correlated with oocyte and embryo quality.
Lu Wang, Jinmei Gao, Jie Ma, Jing Sun, Yajie Wang, Jia Luo, Zhaoyang Wang, Hui Wang, Jialing Li, Danyu Yang, Jinfang Wang, Rong Hu   +11 more
doaj   +1 more source

3. Galileo

, 1958
Of all the early proponents of the Copernican theory, Galileo was perhaps the most renowned and certainly one of the most effective. Galileo Galilei (1564-1642) was educated in the classical, Aristotelian manner.
Bloom, Robert L., Crapster, Basil L., Dunkelberger, Harold A., Glatfelter, Charles H., Mara, Richard T., Richardson, Norman E., Schubart, W. Richard   +6 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Correction to: A Comparison of the Effects of Voluntary and Involuntary Exercise on Behavioral Responses and Serum Levels of IGF-1 and Corticosterone in Ovariectomized Rats with PTSD [PDF]

Journal of Mazandaran University of Medical Sciences
Arvin Amiri1, Majid Khanjani 2, Ali Shoshtari3, Seyed Parsa Seyedpour 4, Kobra Akhoundzadeh 5, Sakineh Shafia6,7 1 Veterinarian, Department of Veterinary Medicine, Faculty of Veterinary Medicine, Babol Branch, Islamic Azad University, Babol, Iran 2 ...
Arvin Amiri, Majid Khanjani, Ali Shoshtari, Seyed Parsa Seyedpour, Kobra Akhoundzadeh, Sakineh Shafia   +5 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source