Results 161 to 170 of about 3,677,242 (302)

Learning medicine. Starting medicine: the basic medical sciences course. [PDF]

BMJ, 1983
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Retraction Note: Epigenetic modification of ferroptosis by non-coding RNAs in cancer drug resistance. [PDF]

Mol Cancer
Wang H, Fleishman JS, Cheng S, Wang W, Wu F, Wang Y, Wang Y.   +6 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

AbstractMaster® [PDF]

Master is a powerful search/data management software specifically designed to help quickly locate relevant medical articles indexed by the National Library of Medicine* (NLM), to help keep track searches, what one has read, catalog references and full ...
D. Marr
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Violence-related injuries in the emergency department: an epidemiological cross-sectional study. [PDF]

Int J Emerg Med
Salimi R, Familgarosian S, Mohammadpour A, Heidari B, Jiryaee N, Rezaei B.   +5 more
europepmc   +1 more source

Pure Medical Science and Individualized Medical Care - Internal Medicine as Integrated Medicine

Nihon Naika Gakkai Zasshi, 2007
openaire   +5 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A cross-sectional examination of immune adaptations during pregnancy in the ECHO Cohort. [PDF]

Front Immunol
Banker SM, Shapiro-Thompson R, Sinsel S, Ghassabian A, Douglas C, Nelson ME, Peterson LA, Thyagarajan B, Morales S, Hockett CW, Elliott AJ, Giamberardino SN, Shuffrey LC.   +12 more
europepmc   +1 more source