Results 221 to 230 of about 3,677,242 (302)

Application of the WHO new vaccine introduction prioritisation and sequencing framework to guide evidence-based vaccine introduction decisions in Iran, 2025-2030. [PDF]

BMJ Open
Fotouhi A, Younesian S, Mousavi SM, Zahraei SM, Mahmoudi S, Fotouhi F, Nojomi M, Alavi M, Zamani O, Sedighi I, Nateghian A, Akbari Sari A, Movahedi M, Gharagozlou M, Mamishi S, Salehi M, Biglari A, Es-Haghi A, Moradi G, Gouya MM.   +19 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Erratum to "A single HIIT session does not alter blood sphingolipid levels in healthy young adults: The SphingoHIIT randomized controlled trial". [PDF]

Comput Struct Biotechnol J
Angst T, Weber N, Fischer S, Lehmann J, Infanger D, Teav T, Schwendinger F, Streese L, Hinrichs T, Croci I, Schmied C, Gallart-Ayala H, Höchsmann C, Koehler K, Hanssen H, Schmidt-Trucksäss A, Ivanisevic J, Carrard J.   +17 more
europepmc   +1 more source

Bridging Laser Medicine and Sports Medical Science: History of the Laser Medicine & Sports Science

Nippon Laser Igakkaishi, 2020
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Efficacy and Tolerability of Non-Routine Gastric Residual Volume Monitoring in Mechanically Ventilated Adults Receiving Early Enteral Nutrition: A Randomised Controlled Non-Inferiority Trial. [PDF]

Nurs Crit Care
Zhang H, Chen Y, Li F, He C, Li X, Wang Y, Fan J, Wang J, Xia Y, Guo N, Yu K.   +10 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Study protocol: A randomized controlled trial of chemoradiotherapy versus chemotherapy as neoadjuvant therapy for resectable pancreatic cancer (CSGO-HBP-027). [PDF]

PLoS One
Tomimaru Y, Akita H, Tamari K, Maeda S, Wada H, Iwagami Y, Koga C, Hama N, Tomokuni A, Kobayashi S, Asaoka T, Tsujie M, Tanemura M, Murakami M, Katsura Y, Shimizu J, Yamashita M, Sakamoto S, Okamura S, Yamada T, Doki Y, Eguchi H.   +21 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source