Results 71 to 80 of about 3,654,618 (260)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

アンジオテンシノーゲン遺伝子欠損マウスにおける血液脳関門の異常 [PDF]

, 2000
Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no. 2388, 2000.3.24Joint authors: Hiroshi Hama ... [et al.]Offprint. Originally published in: Nature Medicine, v. 4, no. 9, pp.
Kakinuma Yoshihiko, 柿沼 由彦
core  

Contribution of Hacettepe University Faculty of Medicine to the World’s Biomedical Literature (1988-1997) [PDF]

, 2002
The contribution of Turkish researchers to sciences is increasing. Turkish scientists published more than 6.000 articles in 1999 in scientific journals indexed by the Institute for Scientific Information’s Science Citation Index, which puts Turkey to the
İlhan, Mustafa, Tonta, Yaşar
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Multilevel plasticity and altered glycosylation drive aggressiveness in hypoxic and glucose-deprived bladder cancer cells

iScience
Summary: Bladder tumors with aggressive characteristics often present microenvironmental niches marked by low oxygen levels (hypoxia) and limited glucose supply due to inadequate vascularization.
Andreia Peixoto, Dylan Ferreira, Andreia Miranda, Marta Relvas-Santos, Rui Freitas, Tim S. Veth, Andreia Brandão, Eduardo Ferreira, Paula Paulo, Marta Cardoso, Cristiana Gaiteiro, Sofia Cotton, Janine Soares, Luís Lima, Filipe Teixeira, Rita Ferreira, Carlos Palmeira, Albert J.R. Heck, Maria José Oliveira, André M.N. Silva, Lúcio Lara Santos, José Alexandre Ferreira   +21 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ΔNp63 regulates MDSC survival and metabolism in triple-negative breast cancer

iScience
Summary: Triple-negative breast cancer (TNBC) contributes greatly to mortality of breast cancer, demanding new targetable options. We have shown that TNBC patients have high ΔNp63 expression in tumors.
Ukjin Kim, Rahul Debnath, Javier E. Maiz, Joshua Rico, Satrajit Sinha, Mario Andrés Blanco, Rumela Chakrabarti   +6 more
doaj   +1 more source

Mental and Medical Sciences Today [PDF]

, 2014
Journal of Mind and Medical Sciences is designed as a free online, open access, interdisciplinary and peer-reviewed journal. The JMMS mission is to address ideas and issues related to mind and medicine, publishing scientific review and empirical papers ...
Motofei, Ion G., Rowland, David L.
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Development of an obesity-related multi-gene prognostic model incorporating clinical characteristics in luminal breast cancer

iScience
Summary: Despite adjuvant chemotherapy and endocrine therapy in luminal breast cancer (LBC), relapses are common. Addressing this, we aim to develop a prognostic model to refine adjuvant therapy strategies, particularly for patients at high recurrence ...
Hengjun Zhang, Shuai Ma, Yusong Wang, Xiuyun Chen, Yumeng Li, Mozhi Wang, Yingying Xu   +6 more
doaj   +1 more source