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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Adaptive feature fusion based semi-supervised federated learning system for ECG arrhythmia detection. [PDF]

Front Artif Intell
Regi SA, Srinivasan J, Pandi T.
europepmc   +1 more source

Authorship-for-Sale: From Fake Papers to Forensic Scientometrics. [PDF]

J Med Internet Res
Dominy C.
europepmc   +1 more source

Recent Advances in CRISPR/Cas Systems for Respiratory Pathogen Diagnostics. [PDF]

Viruses
Dai Y, Xia L, Yang Y, Qiao G, Jin X, Mao X.   +5 more
europepmc   +1 more source

Reply to Zoghbi and Innis: Clarifying the cellular basis of GPR84-PET signal in neuroinflammation. [PDF]

Proc Natl Acad Sci U S A
Kalita M, Kuo RC, Reyes ST, Scott PJH, Milligan G, James ML.   +5 more
europepmc   +1 more source

How the mosquito's carbon dioxide sense gets an internal boost. [PDF]

PLoS Biol
Su CY.
europepmc   +1 more source

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Medical device active surveillance of spontaneous reports: A literature review of signal detection methods

Pharmacoepidemiology and Drug Safety, 2020
AbstractPurposeThe collection and analysis of real‐world data for the active monitoring of medical device performance and safety has become increasingly important. Spontaneous reports, such as those in the Food & Drug Administration's (FDA's) Manufacturer and User Facility Device Experience (MAUDE), provide early warning of potential issues with ...
Andrew Yoo, Gary Chung
exaly   +3 more sources