Results 151 to 160 of about 10,088,500 (301)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Near-Field Localization and Sensing With Large-Aperture Arrays : From signal modeling to processing

The signal processing community is currently witnessing a growing interest in near-field signal processing, driven by the trend toward the use of large-aperture arrays with high spatial resolution in the fields of communication, localization, sensing ...
Ramezani, Parisa,, Björnson, Emil,, Liu, Yuanwei,, Liu, Yuanwei, Björnson, Emil, Wang, Zhaolin, Ramezani, Parisa, Wang, Zhaolin,   +7 more
core   +1 more source

Real-Time SpO₂ Estimation from Chest Reflectance Photoplethysmography: Algorithm Development and Clinical Validation Against Arterial SaO₂. [PDF]

Sensors (Basel)
Lee W, Shin J, Song M, Song MK, Kim KM, Noh GJ, Cho S.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Postprocessing Software Tool for 1H and 31P MRI Data Analysis. [PDF]

Top Magn Reson Imaging
Kassey VB, Walle M, Egan J, Kassey DV, Yeritsyan D, Wu Y, Snyder BD, Rodriguez EK, Ackerman JL, Nazarian A.   +9 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Signal Processing Techniques in Mobile Communication Systems - Signal Separation, Channel Estimation and Equalization

, 2005
Over the last decade there has been an explosive growth in the use of wireless mobile communications. Second generations systems are mature technologies now and third generation systems and beyond are being implemented and researched.
Landqvist, Ronnie
core  

Relevance of the uMap Collaborative Platform as Support for Choropleth Mapping of a Traffic-Light Statistical Signal Atlas of All-Cause Mortality During the First French Lockdown: Geospatial Analysis. [PDF]

JMIR Med Inform
Quesnel-Barbet A, Pages T, Soula J, Maignant G, Hansske A.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cardiac interoception in chronic pain: no association between interoceptive accuracy and symptom report. [PDF]

Front Psychiatry
Thomas MV, Schulz A, van Ryckeghem DML, Lutz APC, Lambracht K, Adermann J, Vögele C.   +6 more
europepmc   +1 more source