Results 51 to 60 of about 620,434 (349)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Factors influencing the specialty field choices of medical school graduates

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2003
Background and Objective: Growing national concern about large increase in the number of medical school graduates, specialty choice and availability of the physicians to medical services specially after cultural revolution due to challenges.
M Zarghami, V Ghaffari Saravi, AR Khalilian, AR Sefidchian   +3 more
doaj  

The impact of patients' chronic disease on family quality of life : an experience from 26 specialties [PDF]

, 2013
BACKGROUND: Previous studies have assessed family quality of life in individual disease areas and specialties. The aim of this study was to investigate the impact of disease on family members of patients over a wide range of specialties and identify key ...
Basra, Mohammad Khurshid Azam, Finlay, Andrew Yule, Golics, Catherine Jane, Salek, M Sam   +3 more
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

EVALUATION OF NUCLEAR MEDICINE AWARENESS IN NIGERIA; PERSPECTIVE OF LAGOS STATE RADIOGRAPHERS [PDF]

Kanem Journal of Medical Sciences, 2019
Background: Diagnostic Nuclear Medicine makes use of radioisotopes with the aid of ionizing radiation for the early diagnosis of disease conditions.
Sowunmi AC, Babatunde EO, Popoola A, Olatunji T, Ololade K   +4 more
doaj   +1 more source

A cross-sectional study of student empathy across four medical schools in Denmark—associations between empathy level and age, sex, specialty preferences and motivation [PDF]

, 2022
Elisabeth Assing Hvidt, Jens Søndergaard, Sonja Wehberg, Niels Christian Hvidt, Christina Maar Andersen   +4 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Emotional intelligence and medical specialty preference – findings from the empirical study

Psychiatria i Psychologia Kliniczna, 2012
Aim of the study: Literature emphasizes a positive impact of emotional intelligence on interpersonal and commu‑ nication skills, the doctor‑patient relationship, and the level of empathy.
Agnieszka Pawełczyk, Magdalena Kotlicka‑Antczak, Janusz Śmigielski, Tomasz Pawełczyk, Jolanta Rabe‑Jabłońska   +4 more
doaj  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source