Results 71 to 80 of about 620,434 (349)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Specialty choice among final-year medical students and house officers in Nigeria: implications for anaesthesia practice – a cross-sectional study

BMJ Open
Objectives Nigeria’s doctor shortage is worsening with mass exodus and imbalanced specialty distribution. Anaesthesia faces particularly critical shortages.
Thankgod Chukwunnonso Okonkwo, Gbolahan Deji Olatunji, Victor Mayowa Adeleye, Mukaila Oyegbade Akinwale   +3 more
doaj   +1 more source

Commentary on Trends in Child Health Insurance Coverage: A Local Perspective [PDF]

, 2013
Purpose: To provide commentary on the original research article, “Trends in Child Health Insurance Coverage: A Local Perspective,” by Jean Rapahel, Richard R. Batsell, Marc A. Kowalkowski, Aileen Beltran, Angelo P. Giardino, and Charles G.
Bocchini, Claire Elizabeth
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A Novel Tool for the Evaluation of Residency Training: Scale Development and Validation

İstanbul Medical Journal
Introduction: The purpose of medical specialty training is to provide the physician with sufficient knowledge, skills, attitudes, and qualifications in the chosen field of medicine.
Nazan Karaoğlu, Ümmü Doğan, Aşir Genç, Nur Demirbaş, Fatih Yılmaz, Hatice Küçükceran, Fatma Gökşin Cihan, Ümran Münire Kahraman   +7 more
doaj   +1 more source

Induction Implications: Shaping the Competence and Confidence of Junior Doctors Within Complex Medical Specialties [PDF]

, 2023
Tareq Al Saoudi, Kanika Chawla, Farah Khasawneh, Cristina Pollard, John Isherwood, Neil Bhardwaj, Giuseppe Garcea, Ashley R. Dennison   +7 more
openalex   +1 more source

How Much Do Medical Students Know About Physician Income? [PDF]

Twenty-five cohorts of medical students were asked in their first and fourth year of school to estimate contemporaneous physician income in six different specialties.
Sean Nicholson
core  

The Question of Competence: Reconsidering Medical Education in the Twenty-First Century [PDF]

, 2013
[Excerpt] The real challenge for those involved in designing competency-based educational programs is to recognize the complexity of competence as a concept. Only then can they effectively delineate the knowledge, skills, and attitudes that learners must
Hodges, Brian D, Lingard, Lorelei
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source