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The structure and assembly principles of a two‐component encapsulin nanocompartment shell are reported. The two‐component protein compartment self‐assembles from two distinct HK97‐fold shell proteins into a pseudo‐icosahedral protein shell with variable composition and irregular tiling.
Cassandra A. Dutcher+2 more
wiley +1 more source
Knowledge of Pharmacology of Analgesics Among Nurses in a Tertiary Centre [PDF]
Objectives: To evaluate the knowledge of nurses about the analgesics they administer in our hospital. Methodology: A total of 102 nurses completed the questionnaire which included 20 multiple choice questions based on the dosage forms, mechanism of ...
D'Silva, SA, Padmaja, U, Pereira, NR
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STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches
This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan+10 more
wiley +1 more source
Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermediate state that initiates aggregation into amyloid fibrils.
Minkoo Ahn+6 more
wiley +1 more source
Combining the bichloride‐based ionic liquid [NEt3Me][Cl(HCl)n] with PdCl2 results in the formation of the highly active, mercury‐free catalyst [NEt3Me]2[PdCl4] for acetylene hydrochlorination to vinyl chloride. Replacing HCl with the bichloride improves the process safety and achieves a competitive turnover frequency of 110 molVCM h−1 molPdCl2−1.
Gesa H. Dreyhsig+9 more
wiley +1 more source
Antimicrobial effect of Ruta graveolens extract on pathogenic bacteria
Background and Objective: Ruta graveolens is a plant used in traditional medicine with variety of therapeutic effects. This study was done to evaluate the antimicrobial effect of hydro and alcoholic extracts of Ruta graveolens on 8 species of pathogenic ...
Ahmadi Jalali Moghadam M+3 more
doaj
The Design of a new NICU Patient Area: Combining Design for Usability and Design for Emotion [PDF]
In the design of medical products both usability and emotional experience are important to be considered. Usability can enhance the work situation of medical staff and ensure patient safety.
Garde, Julia, van der Voort, Mascha
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