Results 161 to 170 of about 1,082,092 (262)

Mental health and the knowledge and attitude towards insomnia among medical staff in China: a cross-sectional study. [PDF]

BMJ Open
Tang T, Zhang N, Qu L, Zhang J, Yang D, Shen S, Du B, Du X, Liu N, Cui L.   +9 more
europepmc   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Editorial: Patient and medical staff safety and healthy work environment in the 21st century. [PDF]

Front Public Health
Friganovic A, Boskovic S, Krupa Nurcek S, Kovacevic I, Kosydar-Bochenek J, Filipovic B.   +5 more
europepmc   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Psychological impact of an epidemic on the mental health of medical staff: a case study of mobile cabin hospitals in Beijing during the COVID-19 pandemic. [PDF]

Front Public Health
Ni YT, Wang JF, Wang MN, Shen LB, Li QD, Liang L, Sun J, Xiao NA, Liu JH, Du X, Wang J, Fu YB.   +11 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

A mediating effect of sense of coherence on the association between work-family conflict and workplace ostracism among medical staff. [PDF]

Front Psychiatry
Li N, Zhang H, Zhao H, Zhang C, Zhang H, Ma F, Tang X, Wang C, Huang J.   +8 more
europepmc   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Correction: Community-based palliative care needs and barriers to access among cancer patients in rural north India: a Participatory action research

BMC Palliative Care
Mayank Gupta , Ankita Kankaria, Liya E. Joshy, Sandeep Singh, Bhajan Lal, Subhash Choudhary, Sapna Marcus, Anju Grewal, Lajya Devi Goyal, Rakesh Kakkar   +9 more
doaj   +1 more source

Psychological and behavioral mechanisms that drive medical staff's engagement in kidney palliative care-an empirical analysis from medical staff in mainland China. [PDF]

BMC Health Serv Res
Zhu W, Wu M, Zhang S, Li R, Liu T, Zhou Y, Guan Y, Xia J.   +7 more
europepmc   +1 more source