Results 161 to 170 of about 10,865,771 (329)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Medical students’ career preferences in Bangladesh [PDF]

Mohammad Azmain Iktidar, Md Muid Sakib, Ummi Rukaiya Munni, Fahmida Hoque Rimti, Renessa Yousuf, Koushik Majumder, Tirtha Saha, Farhat Lamisa Golpo, Md Samee U Sayed, Sabrina Monsur, Asadul Al Galib, Md Kamran Hossain, Sigma Alam Shupti, Noshin Nawar, Sudeshna Mazumder, M. Tasdik Hasan   +15 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Skills Training in Laboratory and Clerkship: Connections, Similarities, and Differences [PDF]

, 2003
Context: During the third semester of a 6 year long curriculum medical students train clinical skills in the skills laboratory (2 hours per week for 9 weeks) as well as in an early, 8 week clinical clerkship at county hospitals.
Eika , M.D., Ph.D., Berit, Guldbrand, Dorte, Moercke , M.D, Nielsen, Anne Mette, Wickmann-Hansen , M.Ed, Gitte   +3 more
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Are the healers healthy? Exploring non-communicable diseases among healthcare workers in Ajman, United Arab Emirates

BMC Public Health
Background Non-communicable diseases (NCDs), particularly cardiovascular diseases, are a major cause of global mortality. In the Gulf Cooperation Council (GCC) nations, healthcare workers face increased risks of obesity, hypertension, and diabetes due to
Sandhra Treesa Santhosh, Abubakker Siddiq Mohamed Hameed, Anugraha Lisa Ciju, Aaesha Rannath, Syeda Kaunain Fatima, Janet Chichu James, Mohammed Nayeem Shaji, Ehab M Esheiba, Jayadevan Sreedharan, Jayakumary Muttappallymyalil   +9 more
doaj   +1 more source

Research in medical education [PDF]

, 2009
The year 2009 saw a number of developments in Medical Education in Malta that were initiated as a result of a commitment to revising the medical curriculum in order to meet the challenges in medical education.
Vassallo, Josanne
core  

Breast self-examination among female medical students at Damascus University: A cross-sectional study [PDF]

Mohammed Alshafie, Anas Bitar, Massa Alfawal, Mhd Basheer Alameer, Dima Alhomsi, Maher Saifo   +5 more
openalex   +1 more source

An exploration of the effect of simulation on perceptions of medical students’ preparedness for professional practice; a mixed-methods, longitudinal study

, 2020
Ciara Carpenter
openalex   +1 more source

Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis.

Journal of the American Medical Association (JAMA), 2016
Lisa S. Rotenstein, M. Ramos, M. Torre, J. Segal, Michael J. Peluso, C. Guille, S. Sen, Douglas A. Mata   +7 more
semanticscholar   +1 more source