Results 121 to 130 of about 610,652 (382)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Subject metadata support powered by Maui [PDF]

, 2010
Selecting subject headings and keywords is a chore for all metadata editors, who often leave these fields blank or incomplete—even when there are no guidelines and any word or phrase can be chosen.
Medelyan, Olena, Perrone, Vye, Witten, Ian H.   +2 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A systematic review on the association of serum selenium and metabolic syndrome

Journal of Research in Medical Sciences, 2015
Background: This systematic review paper aims to study the experimental and human studies on the relationship between metabolic syndrome (MetS), its component and selenium (Se) concentration.
Mohammad Hasan Tajaddini, Mojtaba Keikha, Ali Razzazzadeh, Roya Kelishadi   +3 more
doaj   +1 more source

Dynamic literature mapping : typography in screen-based media [PDF]

, 2003
This paper chronicles the development of a visual map representing a literature search on key theorists and thinkers in two principal topics: Typography and New Media.
Yee, Joyce
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

KRAS and BRAF Mutations as Prognosis Factors in Breast Cancer

Health Research in Africa
Introduction. Breast cancer is most often linked to genetic factors. The main signaling pathways encountered in this pathology are PIK3/AKT/mTOR and RAS/RAF/MEK/ERK. The latter is much less activated in breast cancer.
Ngo Pambe CJ, Rissia F, Mendimi Nkodo JM, Serrano JL   +3 more
doaj   +1 more source

Tezaurus Medical Subject Headings – MeSH

Vjesnik Bibliotekara Hrvatske, 2011
Tezaurus Medical Subject Headings (MeSH) nadzirani je rječnik koji izrađuje Nacionalna medicinska knjižnica Sjedinjenih Američkih Država. Koristi se za predmetnu obradu, indeksiranje i pretraživanje publikacija iz područja biomedicine i zdravstva. Tezaurus sačinjavaju nizovi deskriptora organiziranih u abecednu i hijerarhijsku strukturu. Izdanje MesH-a
openaire   +4 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source