Results 81 to 90 of about 541,947 (315)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Application of Social Network Analysis to Health Care Sectors [PDF]

Healthcare Informatics Research, 2012
ObjectivesThis study aimed to examine the feasibility of social network analysis as a valuable research tool for indicating a change in research topics in health care and medicine.MethodsPapers used in the analysis were collected from the PubMed database
Hae Lan Jang, Young Sung Lee, Ji-Young An   +2 more
doaj   +1 more source

Peripheral Neuropathy in Systemic Autoimmune Rheumatic Diseases—Diagnosis and Treatment

Pharmaceuticals, 2023
Peripheral neuropathy (PN) is frequently observed in systemic rheumatic diseases and is a challenge in clinical practice. We aimed to review the evidence on the subject and proposed a comprehensive approach to these patients, facilitating diagnosis and ...
Jean Marcos De Souza, Thiago Junqueira Trevisan, Samara Rosa Sepresse, Ana Carolina Londe, Marcondes Cavalcante França Júnior, Simone Appenzeller   +5 more
doaj   +1 more source

Subject metadata support powered by Maui [PDF]

, 2010
Selecting subject headings and keywords is a chore for all metadata editors, who often leave these fields blank or incomplete—even when there are no guidelines and any word or phrase can be chosen.
Medelyan, Olena, Perrone, Vye, Witten, Ian H.   +2 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Die Zukunft des Deutschen MeSH: Vom Übersetzungsprozess zum Terminologie-Service

GMS Medizin – Bibliothek – Information, 2020
The poster outlines which services and goals ZB MED has set itself by assuming responsibility for the German MeSH, the current status, future tasks and the relevance of the professional community in setting up our services.
Wollnik-Korn, Gabriele, Fischer-Wagener, Brigitte, Langnickel, Lisa, Schneider, Julian, Baum, Roman, Fluck, Juliane   +5 more
doaj   +1 more source

Hyaluronic acid: perspectives in upper aero-digestive tract. A systematic review [PDF]

, 2015
Background: To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT).
Baptista, Peter, Casale, Manuele, Moffa, Antonio, Oliveto, Giuseppe, Pace, Annalisa, Sabatino, Lorenzo, Salvinelli, Fabrizio, Vitali, Massimiliano   +7 more
core   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Improving PubMed Search Using Medical subject heading ( MeSH) Terms

Global Journal of Medical Therapeutics, 2023
Medical Subject Headings (MeSH) terms are valuable tools to conduct focused and concise search. This review article evaluates the performance of search strategies for retrieval of information from the national Library of Medicine (NLM) by using the Medical Subject Headings (MeSH) while searching for articles about analgesics used for pain management in
Mahvish Umar, Sadaf Sharif, Sana Younas
openaire   +1 more source