Results 81 to 90 of about 70,943 (252)

Filtering failure: the impact of automated indexing in Medline on retrieval of human studies for knowledge synthesis

open access: yesJournal of the Medical Library Association
Objective: Use of the search filter ‘exp animals/ not humans.sh’ is a well-established method in evidence synthesis to exclude non-human studies. However, the shift to automated indexing of Medline records has raised concerns about the use of subject ...
Nicole Askin, Tyler Ostapyk, Carla Epp
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A survey of Compliance of Persian Abstracts of Research Articles in Medical Journals of Universities of Medical Sciences (Type 1) with the Vancouver Guideline and ISO 214 Standard [PDF]

open access: yesJournal of Kerman University of Medical Sciences, 2015
Background & Aims: An abstract is the best source of information within a content. The structured abstract is the best representation of the main source. Writing an appropriate abstract requires adherence to standards of abstracting.
Nasrin Makani   +2 more
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

The Primary Care Electronic Library: RSS feeds using SNOMED-CT indexing for dynamic content delivery

open access: yesJournal of Innovation in Health Informatics, 2006
Background Rich Site Summary (RSS) feeds are a method for disseminating and syndicating the contents of a website using extensible mark-up language (XML).
Judas Robinson   +5 more
doaj   +1 more source

MEDICAL SUBJECT HEADINGS IN MEDLARS.

open access: yesBulletin of the Medical Library Association, 1996
Use of an identical subject heading list for both machine searching and publication creates problems. Necessary compromises include precoordination of some headings for publication and use of some coordinates in the computer system that are not appropriate for a printed index.
openaire   +1 more source

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