Results 281 to 290 of about 1,943,319 (338)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

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Computerization of medical technologies

Biomedical Engineering, 1996
The object of computerization is practical medical technology which is regarded as a complex of methodological and instrumental support for maintaining a physician-patient dialogue. The methodological support remain to be a prerogative of medicine and, consequently, relatively conservative. The instrumental support (as an aid for the methodological one)
Losev Ir, M V Pilina, Lemenkov Va, Kaliadin Ni, L I Chalyĭ   +4 more
openaire   +3 more sources

Surveillance of Medical Technologies

Journal of Public Health Policy, 1986
Technologies from three different medical disciplines are examined in an effort to demonstrate the potential benefit of epidemiologic surveillance of health care technologies. Tubal sterilization is a common surgical procedure done in a healthy population, and a surveillance mechanism is already in place.
Ruth L. Berkelman, Stephen B. Thacker
openaire   +3 more sources

Medical and medical-technological developments [PDF]

, 1987
The amazing strides in medicine and social facilities during the last century, manifested in better health care facilities, hygiene, vaccination, the introduction of antibiotics etc., have had the effect of doubling life expectancy at birth in the industrialized countries. 1)
Henk A. Becker, C. F. Hollander
openaire   +1 more source

The NICE Medical Technologies Advisory Committee and medical technologies guidance [PDF]

Heart, 2011
The Medical Technologies Advisory Committee (MTAC) is the driver of the National Institute for Health and Clinical Excellence (NICE) Medical Technologies Evaluation Programme (MTEP). This aims to identify novel devices and diagnostics with plausible claims for advantages to patients and/or to the NHS.
openaire   +2 more sources

Medical Technology

Health Care Management Review, 1980
Technology was once considered automatically beneficial. Today the health care industry is carefully weighing the consequences as well as the advantages of medical technology. Medical technology has become a policy issue of great importance in public and private sectors.
Clyde J. Behney, David Banta
openaire   +3 more sources

Adopting Medical Technology

Medical Decision Making, 2014
New technologies are often incorporated into clinical practice with few data on their benefits and risks. In this issue of Medical Decision Making, Gold and colleagues report results of interviews with radiation oncologists and surgeons about factors that led to adoption of one treatment, accelerated partial breast irradiation (APBI).
openaire   +3 more sources