FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Simulated patient and role play methodologies for communication skills and empathy training of undergraduate medical students [PDF]
, 2020 Cristina Bagacean +9 more
openalex +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Debating DSM-5:diagnosis and the sociology of critique [PDF]
, 2013 The development of the fifth edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders—the DSM-5—has reenergised and driven further forward critical discourse about the place and role of diagnosis in mental ...
Callard +33 more
core +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Six months exclusive breastfeeding : a relational behaviour influenced by actual and virtual social networks : a thesis presented in fulfilment of the requirements for the degree Doctor of philosophy in Midwifery, Massey University, Manawatu, New Zealand [PDF]
, 2017 Six months exclusive breastfeeding:|ba relational behaviour influenced by actual and virtual social networks : a thesis presented in fulfilment of the requirements for the degree Doctor of philosophy in Midwifery, Massey University, Manawatu, New ...
Alianmoghaddam, Narges
core
Mapping the drivers of overdiagnosis to potential solutions [PDF]
, 2017 Thanya Pathirana and colleagues explore strategies to tackle the problem of too much medicine. Key messages: Interest is growing in tackling the problems of overdiagnosis and overtreatment. Possible drivers and potential solutions arise across five inter-
Clark, Justin +2 more
core +1 more source
MedFusionGAN: multimodal medical image fusion using an unsupervised deep generative adversarial network [PDF]
, 2023 Mojtaba Safari +2 more
openalex +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source