Results 301 to 310 of about 5,128,864 (333)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley +1 more source
Primary healthcare's carbon footprint and sustainable strategies to mitigate its contribution: a scoping review. [PDF]
BMC Health Serv ResWalsh SJ +5 more
europepmc +1 more source
Immune checkpoint blockade and transarterial chemoembolization in liver-limited hepatocellular carcinoma: new questions at the dawn of a new era. [PDF]
J Immunother CancerDhyani A, Harding JJ.
europepmc +1 more source
Are menstrual periods an environmental liability? Period poverty and eco-feminist bioethics. [PDF]
BioethicsRichie C.
europepmc +1 more source
Rising incidence of paediatric scurvy - patient database querying does not reveal the whole story - authors' reply. [PDF]
Lancet Reg Health EurAssad Z +4 more
europepmc +1 more source
Breast Cancer Screening in Women With Multiple Sclerosis: A Mixed-Methods Study. [PDF]
Eur J NeurolPierret C, Philippe L, Leray E.
europepmc +1 more source