Abstract The hypothalamic–pituitary–gonadal (HPG) axis coordinates reproductive function and incorporates gonadal sex steroid feedback to regulate gonadotropin secretion in a homeostatic manner. In females, ovarian estrogens and progestins act as the primary negative feedback signals to suppress luteinizing hormone (LH) release, whereas in males ...
Lillian Rose, Alexander S. Kauffman
wiley +1 more source
Upcoming therapies for steatotic liver disease: Translating breakthroughs into clinical practice
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and a leading cause of cirrhosis, hepatocellular carcinoma, and cardiometabolic morbidity. Often clinically silent until advanced fibrosis develops, management has largely relied on lifestyle interventions, with limited ...
Philip N. Newsome, Saima Ajaz
wiley +1 more source
The Development of the European Sleep Questionnaire A New Patient‐Reported Outcome Measure
ABSTRACT Sleep medicine relies on patient‐reported outcome measures (PROMs) to complement clinical interviews and objective sleep tests. Available sleep questionnaires focus on isolated symptoms or single disorders, limiting their ability to capture the complexity of sleep conditions. Also, many PROMs remain poorly validated.
Dirk A. Pevernagie +20 more
wiley +1 more source
Patients with persistent medically unexplained physical symptoms: a descriptive study from Norwegian general practice. [PDF]
Aamland A, Malterud K, Werner EL.
europepmc +1 more source
ABSTRACT Background Guillain‐Barré syndrome (GBS) is an acute, immune‐mediated polyradiculoneuropathy most often triggered by infections such as Campylobacter jejuni, Epstein–Barr virus (EBV), or cytomegalovirus (CMV). Although transplant‐associated GBS is recognized in adults, it remains rare in pediatric recipients, and distinguishing immune‐mediated
Liora Rabizadeh, Paola Pergami
wiley +1 more source
GP consultations for medically unexplained physical symptoms in parents and their children: a systematic review. [PDF]
Shraim M, Mallen CD, Dunn KM.
europepmc +1 more source
The Influence of Running Cadence Manipulation on Acute Cartilage Response in Distance Runners
ABSTRACT We examined the influence of running cadence manipulation on femoral cartilage deformation in runners and assessed the association between knee biomechanics and cartilage characteristics. Thirty‐one runners (15 females and 16 males) completed a habitual and high cadence (+10%) run 2–7 days apart in a counterbalanced order.
Ryan J. Evans +4 more
wiley +1 more source
Identifying patients with medically unexplained physical symptoms in electronic medical records in primary care: a validation study. [PDF]
den Boeft M +5 more
europepmc +1 more source
Patients' experience with medical communication about medically unexplained symptoms. [PDF]
Rambaud E, Tran VT, Lenfant T, Ranque B.
europepmc +1 more source
Thwarted credibility work and double binds in medically unexplained pain in Japan: a qualitative study. [PDF]
Okuhara T, Okada H, Yokota R, Kagawa Y.
europepmc +1 more source

