Results 111 to 120 of about 1,460,022 (262)

Model‐Informed Approaches for Pediatric Type 2 Diabetes Evidence Generation: Insights from a Model‐Based Longitudinal HbA1c Meta‐Analysis from EMA Marketing Authorization Applications

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Evidence generation for antihyperglycemic therapies in pediatric type 2 diabetes mellitus (T2DM) remains challenging, with most randomized trials failing to demonstrate statistically significant reductions in glycated hemoglobin (HbA1c), partly due to substantial between‐subject variability.
Pieter J. Colin   +2 more
wiley   +1 more source

Education on medically unexplained symptoms: a systematic review with a focus on cultural diversity and migrants. [PDF]

open access: yesEur J Med Res, 2023
Mariman A   +6 more
europepmc   +1 more source

A practical difference from the normal approach to evaluate natural killer (NK) cells and NK cell neoplasms by flow cytometry

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Natural killer (NK) cell neoplasms span indolent to highly aggressive entities, and flow cytometric immunophenotyping is central to their detection and classification. However, distinguishing reactive from neoplastic NK cell expansions can be challenging because NK cells lack somatically recombined antigen receptors, and reactive states may ...
Aaron J. Wilk   +7 more
wiley   +1 more source

The Prediction of Somatic Symptom Disorder Based on Demographic Characteristics, Social Isolation, and Perceived Anxiety [PDF]

open access: yesMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk
Introduction: Sociodemographic factors and perceived anxiety have a significant impact on the development of somatic symptom disorder. This study aimed to investigate the role of demographic characteristics, social isolation, and perceived anxiety in ...
Ahmad Ansarifar   +2 more
doaj  

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya   +9 more
wiley   +1 more source

A novel fast detection algorithm for depression based on 3-channel EEG signals

open access: yesFrontiers in Neuroscience
Medically unexplained symptoms (MUS) are an emerging field in current research. Among middle-aged and elderly patients, most MUS symptoms are mainly caused by depression, but early symptoms do not meet the international somatization standards, which ...
XiWu Guo, ZiHan Guo, TaoLi Xie
doaj   +1 more source

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot   +8 more
wiley   +1 more source

How do patients interpret terms for medically unexplained symptoms?

open access: yes, 2012
OBJECTIVE: To investigate how primary care patients interpret the existing terminology used to describe medically unexplained symptoms; to contribute to the current academic discussion on unequivocal terminology.DESIGN: Descriptive cohort study.METHODS ...
Moddejonge, Raquel S   +3 more
core   +2 more sources

Medically unexplained visual symptoms in children and adolescents: an indicator of abuse or adversity?

open access: yes
Purpose To highlight abuse and adversity in childhood as an association of medically unexplained symptoms. Methods Case series. Results Two young adults and one child (all female) are described with medically unexplained impaired vision and diplopia ...
Clarke MP, Porteous AM
core   +5 more sources

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