The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity
Epilepsia Open, EarlyView.Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia +4 more
wiley +1 more source
Epidemiology and organisation of care in medically unexplained symptoms: A systematic review with a focus on cultural diversity and migrants. [PDF]
Int J Clin Pract, 2021 Vermeir P +6 more
europepmc +1 more source
Epilepsia Open, EarlyView.Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar +4 more
wiley +1 more source
Autonomic stress reactivity in patients with medically unexplained physical symptoms
, 2021 The aim of this study is to investigate the autonomic stress reactivity in patients with medically unexplained physical symptoms (overstrain, burnout and functional somatic syndromes), compared to patients with panic disorder and compared to healthy ...
Gielen, Amber, De Wit, Aline
core
Impact of evidence‐based information on horse owners' misconceptions of colic
Equine Veterinary Journal, EarlyView.Abstract Background Misconceptions can be defined as ‘false, persistent beliefs’ or ‘inaccurate, prior knowledge’ and can influence decision‐making. Objectives To investigate the impact of evidence‐based information on UK horse owners' decision‐making for colic. Study Design Mixed‐methods cross‐sectional study.
K. L. Burrell +3 more
wiley +1 more source
Food Chemistry International, EarlyView.The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi +2 more
wiley +1 more source
Advanced Genetics, Volume 6, Issue 1, March 2025.This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley +1 more source
A comparison of emergency department presentations for medically unexplained symptoms in frequent attenders during COVID-19. [PDF]
Clin Med (Lond), 2021 Daniels NF +4 more
europepmc +1 more source
EEG reveals what the eyes can't see: A clinical vignette of epileptic visual loss
Epileptic Disorders, EarlyView.
Zoi Kallia +5 more
wiley +1 more source
Differences of medically unexplained symptoms among patients of different ages and sexes in the psychological clinic of a general hospital and the influencing factors of MUS: A cross-sectional study. [PDF]
Front Psychiatry, 2022 Zhang J +10 more
europepmc +1 more source