Results 71 to 80 of about 68,643 (224)

Progression‐Free Survival 2 as a Potential Surrogate for Overall Survival in Glioblastoma: Insights From a Spanish Multicentric Cohort

Cancer Medicine, Volume 15, Issue 4, April 2026.
Overall, PFS2 correlated more strongly with OS than PFS (0.83 vs. 0.69). PFS2 outperformed PFS in patients with targetable alterations and in those without. Our findings support using PFS2 as a candidate surrogate endpoint in glioblastoma trials. Implementing PFS2 balances trial feasibility with clinical relevance of outcomes.
Jesús Yaringaño, Oriol Mirallas, Víctor Navarro, Diego Gómez‐Puerto, Gabriel Velilla, María Ángeles Vaz, Teresa Gorria, Álvaro Martínez‐Monino, Ainhoa Hernández, María Aguado, Antonio Di Muzio, Daniel López Valbuena, Fiorella Ruiz‐Pace, Macarena González, María Martínez‐García, Guillermo Villacampa, Carmen Balaña, Joan Carles, Rodrigo Dienstmann, Estela Pineda, Juan Manuel Sepúlveda, María Vieito   +21 more
wiley   +1 more source

Análisis de las consecuencias de la desfinanciación de medicamentos del 1 de septiembre de 2012 [PDF]

, 2014
Objetivos: Conocer si la financiación de algunos medicamentos limita su acceso, en especial a las personas con rentas más bajas, valorar la adherencia de los pacientes a dichos medicamentos y analizar el conocimiento de la población sobre dicha medida ...
Arner Navarro, José Antonio, Compairé Bergua, Alberto, Compairé Bergua, Ignacio, García Lerma, Daniel, Ramón Gazo, Agustín   +4 more
core   +1 more source

Anticancer Potential of Piericidin A1 and Derivatives Isolated From Streptomyces sp. Associated With Palythoa variabilis From Brazilian Reefs

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
A Streptomyces spp. strain, isolated from the zoantharian Palythoa variabilis, produces the complex I mitochondrial inhibitor piericidin A1 with effects on cancer cells proliferation and MTT‐formazan reduction at concentrations up to 0.1 aM. ABSTRACT Marine holobionts are an important source of bioactive natural products.
Bianca Del B. Sahm, Katharine G. D. Florêncio, Francisco C. L. Pinto, Ana I. V. Maia, Carlos A. M. Rocha, Paula C. Jimenez, Otília D. L. Pessoa, Tito M. C. Lotufo, Leticia V. Costa‐Lotufo, Diego V. Wilke   +9 more
wiley   +1 more source

Morphine as first medication for treatment of cancer pain

Brazilian Journal of Anesthesiology, 2014
Background and objectives: the medications used according to the recommendation of the World Health Organization do not promote pain relief in a number of patients with cancer pain.
Beatriz C. Nunes, João Batista dos Santos Garcia, Rioko Kimiko Sakata   +2 more
doaj   +1 more source

Caracterización de la automedicación de la población mayor de 18 años residente en el municipio de San Ignacio en Chalatenango [PDF]

, 2010
Al realizar este estudio, se pretende demostrar que tanto logística como analíticamente es posible realizar una recopilación de datos a nivel nacional sobre el tema, lo cual pudiese culminar en una política de automedicación responsable, o al menos en ...
Amaya Reina, Carlos Eduardo Enrique, Quintanilla Flores, Samuel Alejandro   +1 more
core  

Análise do cenário regulatório da renovação de registro de medicamentos genéricos e similares na Agência Nacional de Vigilância Sanitária: subsídio à regulação sanitária do pós-registro de medicamentos

Vigilância Sanitária em Debate, 2020
Introdução: A publicação da Resolução da Diretoria Colegiada da Agência Nacional de Vigilância Sanitária (Anvisa) nº 200, de 26 de dezembro de 2017, fez com que a análise das petições de renovação de registro de medicamentos se tornasse atividade de menor complexidade. Contudo, o número de revalidações automáticas de registro continua expressivo.
openaire   +5 more sources

Introduction of DNA‐HPV test in the Brazilian cervical cancer screening program: When the idea is good but does not fit the budget

International Journal of Gynecology &Obstetrics, Volume 173, Issue 1, Page 157-161, April 2026.
Abstract Objective To evaluate the financial applicability of the DNA‐HPV test for cervical cancer screening in a developing country like Brazil. Methods This was a retrospective, observational study based on documentary data, conducted to assess the cost‐effectiveness of cervical cancer screening strategies in Brazil.
Felipe Polido Urbano, Gabriel Russo Cury, Caio Rodrigo dos Santos, Daniel José Castilho da Silva, José Cândido Caldeira Xavier‐Júnior   +4 more
wiley   +1 more source

Hydroxyl radical footprinting modification reveals an intradomain communication pathway in EFL1 disrupted by a Shwachman‐Diamond syndrome‐associated mutation

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Shwachman‐Diamond syndrome (SDS) is a rare genetic disorder characterized by pancreatic insufficiency and neutropenia. While most cases are linked to mutations in the SBDS gene, some involve mutations in the GTPase EFL1. This protein works with SBDS to release the anti‐association factor eIF6 from the 60S ribosomal subunit during ribosome ...
Jonathan A. Zúñiga‐Domínguez, Rohit Jain, Martín González‐Andrade, Erik R. Farquhar, Mark R. Chance, Abril Gijsbers, Nuria Sánchez‐Puig   +6 more
wiley   +1 more source

Estado actual del intrusismo profesional en el sector veterinario [PDF]

, 2011
Treball presentat a l'assignatura de Deontologia i Veterinària Legal ...
Alcántara Alonso, Sylvia., Carpena Martínez, Sara.   +1 more
core  

Nivel de presión intraocular con el uso de 5-fluorouracilo frente a bevacizumab en pacientes con glaucoma e implante de válvula de Ahmed que presentan quiste de Tenon

Revista Mexicana de Oftalmología, 2015
Objetivo: Determinar el nivel de presión intraocular con el uso de 5-fluorouracilo y de bevacizumab subconjuntival en pacientes con glaucoma e implante de válvula de Ahmed que presentan quiste de Tenon.
Sergio Herrero-Herrera, Berenice Bermúdez-Cruz   +1 more
doaj   +1 more source