Results 51 to 60 of about 70,175 (258)

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Semaglutide vs. liraglutide and incidence of diabetes and cardiovascular disease: A target trial emulation using real‐world data

British Journal of Clinical Pharmacology, EarlyView.
Aims The glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) semaglutide and liraglutide are approved for chronic weight management. Both drugs also have favourable effects on the risk of developing diabetes and cardiovascular disease (CVD) compared with placebo, but their comparative effectiveness for these outcomes is unclear.
Ethan J. Cannon, Wendy Wang, Faye L. Norby, Rob F. Walker, Shalini Kulasingam, Lisa S. Chow, Joel F. Farley, Pamela L. Lutsey   +7 more
wiley   +1 more source

Comparative Outcomes of Transcatheter Versus Surgical Pulmonary Valve Replacement in Adults With Congenital Heart Disease

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Pulmonary valve replacement is frequently required in adults with congenital heart disease (CHD). Comparative real‐world outcomes between percutaneous transcatheter pulmonary valve implantation (TPVR) and surgical pulmonary valve replacement (SPVR) remain incompletely characterized. We evaluated outcomes and resource utilization for
Adam Bolad, Mohamed Elganainy, Fawaz Alenezi, Issam Motairek, Islam Bolad   +4 more
wiley   +1 more source

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, EarlyView.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Socioeconomic Inequities in Eating Disorder‐Related Hospital Utilization Costs in Australia: A Population‐Based Study Using Linked Health Administrative Data

International Journal of Eating Disorders, EarlyView.
ABSTRACT Aims This research aims to explore the extent of socioeconomic inequities in hospital usage costs for individuals with eating disorders (EDs), analyze its trends, and identify associated factors using Queensland (QLD) administrative health linked data from 2013 to 2019. Methods We have utilized the horizontal inequity (HI) approach to quantify
Moin Ahmed, Morgan Sidari, Amy Hannigan, Tania Withington, Salvatore Catania, Michelle Boyd, Warren Ward, Jane Miskovic‐Wheatley, Stephen Touyz, Natasha Nassar, Sarah Maguire, Michelle Cunich   +11 more
wiley   +1 more source

Evaluating the Feasibility, Acceptability, and Preliminary Effectiveness of Interprofessional Enhanced Cognitive Behavior Therapy for Anorexia Nervosa and Atypical Anorexia Nervosa: A Pilot Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Enhanced Cognitive Behavior Therapy (CBT‐E) is the leading outpatient treatment for eating disorders but is typically delivered by a single clinician and does not routinely incorporate interprofessional expertise. In broader healthcare settings, Interprofessional collaborative practice (IPCP), characterized by role clarity, shared ...
Megan Bray, Gabriella Heruc, Susan Byrne, Kate Fleming, Olivia R. L. Wright   +4 more
wiley   +1 more source

Forecasting heart failure: Seasonal alignment of heart failure outcomes in New York

ESC Heart Failure, Volume 12, Issue 2, Page 819-831, April 2025.
Abstract Background Seasonal variations have been observed in heart failure (HF) hospitalization. Numerous explanatory mechanisms have been proposed, but no prior studies have examined potential contributors directly. Our objective was to identify specific factors that could contribute to seasonal variability using a large longitudinal dataset of HF ...
Prerna Gupta, Ellen Brinza, Prateeti Khazanie, Pamela N. Peterson, P Michael Ho, David P. Kao   +5 more
wiley   +1 more source

Comparative performance of risk prediction indices for mortality or readmission following heart failure hospitalization

ESC Heart Failure, Volume 12, Issue 2, Page 1227-1236, April 2025.
Comparative performance of 7 risk prediction indices in patients hospitalized for heart failure. In this cohort of 1206 patients, the LENT index offered the greatest discrimination, calibration, and overall accuracy in predicting 30‐day composite all‐cause mortality or readmission following hospitalization for heart failure.
Tauben Averbuch, Ali Zafari, Shofiqul Islam, Shun Fu Lee, Rajiv Sankaranarayanan, Stephen J Greene, Mamas A Mamas, Ambarish Pandey, Harriette GC Van Spall   +8 more
wiley   +1 more source

Healthcare Professionals’ Experiences of Barriers and Facilitators to ARFID Identification, Diagnosis and Treatment: A Rapid Review

European Eating Disorders Review, EarlyView.
ABSTRACT Objectives Despite increasing evidence of the physical and psychosocial impairments associated with Avoidant/Restrictive Food Intake Disorder (ARFID), there are currently no national guidelines for its assessment and treatment. In the absence of such guidance, it is crucial to understand the experiences of healthcare professionals (HCPs ...
Sandra‐Eve Bamigbade, Freya Cooper, Amanda Ludlow   +2 more
wiley   +1 more source