Results 231 to 240 of about 1,694,268 (297)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Trends in annual medication possession in older adults with type 2 diabetes. [PDF]

J Manag Care Spec Pharm
Dombrowski SK, An J, Lewis M, Hayduk VA, Neugebauer R, O'Connor PJ, Rodriguez LA, Schmittdiel J, Hooker SA, Karter AJ, Oshiro CES, Cassidy-Bushrow AE, Nolan MB, Gilliam LK, Graham J, Wright EA.   +15 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

When You Hear Hoofbeats, It May Still Be the Medication: A Case of Aripiprazole-Induced Hypersexuality Masquerading as Psychiatric Decompensation. [PDF]

Case Rep Psychiatry
Cudjoe N, Jenkins TC, Stallworth B, Mwai CK, Morgan A.   +4 more
europepmc   +1 more source

Improving Medication Safety for Patients with Adrenal Insufficiency Using Electronic Health Record Optimization. [PDF]

Pediatr Qual Saf
Gupta M, Huang A, Ness K, Carlin K, Rutman L.   +4 more
europepmc   +1 more source

Rational Drug Use Support System: design, artificial intelligence integration, and pilot feasibility trial. [PDF]

Rev Assoc Med Bras (1992)
Kahraman M, Bozkurt ME, Kotan S, Ozturk BN, Aydın R, Hatipoğlu S, Eris HA, Erturk MA, Aydin MA, Karan MA.   +9 more
europepmc   +1 more source

Medication and Procedural Abortion and Risk of Psychotropic Medication Use.

JAMA Psychiatry
Steinberg JR, Laursen TM, Lidegaard Ø, Munk-Olsen T.   +3 more
europepmc   +1 more source