Results 21 to 30 of about 462,118 (243)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Medication errors [PDF]

Nurse Prescribing, 2018
In its report of the Short Life Working Group on reducing medication-related harm, the Department of Health and Social Care (DHSC) (2018) provided a UK response to the World Health Organization's (WHO) (2017) Global Patient Safety Challenge, ‘Medication without Harm’. WHO (2017) recognised that there is significant harm caused to patients globally as a
openaire   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

The need for medication reconciliation: a cross-sectional observational study in adult patients [PDF]

, 2011
SummaryBackgroundPoor communication of drug therapy at care interface often results in medication errors and adverse drug events. Medication reconciliation has been introduced as a measure to improve continuity of patient care.
Knez, Lea, Laaksonen, Raisa, Mrhar, Ales, Rezonja, Renata, Suskovic, Stanislav   +4 more
core   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

What You Need to Know about Bar-Code Medication Administration [PDF]

, 2019
Medication errors are the most common type of preventable error. Bar-code medication administration (BCMA) technology was designed to reduce medication administration errors.
Kuhlmann, Martha, DNP, MSN, RN, FNP, PMHCNS-BC, APRN, McBee, Marie E, DNP, MSN, Patterson, Pam, DNP, MSN, NE-BC   +2 more
core   +1 more source

Learning from error: identification and analysis of causative factors leading to medication error in an inpatient hospital setting [PDF]

, 2016
Background: Medication errors are preventable causes of medical error. These errors may happen at various steps of medication process. This study tries to find common errors during four stages i.e. prescribing, transcribing, dispensing and administration.
Kumar, Subodh, Madhwar, Anju, Pathak, Anuj Kumar, Saikia, Dibyajyoti   +3 more
core   +2 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

The effect of a clinical pharmacist discharge service on medication discrepancies in patients with heart failure [PDF]

, 2010
Objective: Heart failure patients are regularly admitted to hospital and frequently use multiple medication. Besides intentional changes in pharmacotherapy, unintentional changes may occur during hospitalisation.
A Kripalani, A Michalsen, Albert W. Lenderink, BL Svarstad, C Duggan, C Moore, CO Phillips, Dm Omori, DSF Yu, EA Coleman, EC Rainville, F Karapinar-Çarkit, H Bolas, JD Wong, JE Doormaal van, Jos W. M. G. Widdershoven, M von Korff, MD Murray, Patricia M. L. A. Bemt, PC Walker, PM Bemt Van den, Rixt Nynke Eggink, S Stewart, SA Al-Rashed, SH Koshman, T Jaarsma, T Vira, TM Koelling   +27 more
core   +3 more sources