Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Advances in Pharmacological and Pharmaceutical SciencesA European legislation was put in place for the reporting of medication errors, and guidelines were drafted to help stakeholders in the reporting, evaluation, and, ultimately, minimization of these errors. As part of pharmacovigilance reporting, a proper
Christophe Dessart +4 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Development and Psychometric Validation of a Questionnaire to Evaluate Knowledge and Attitude Towards Medication Error Reporting Among Pharmacists. [PDF]
Drug Healthc Patient Saf, 2020 Mamat R, Awang SA, Ab Rahman AF.
europepmc +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Barriers to Reporting Medication Errors in Nurses of Teaching Hospitals in Gorgan City in 2021 [PDF]
تحقیقات سلامت در جامعهIntroduction and purpose: Medications are the most common therapeutic intervention, and the safe use of medication and the existence of processes to improve the safety of medicine are of prime importance.
Mohammad Javad Kabir +4 more
doaj
Barriers to medication administration error reporting in a tertiary hospital in Lebanon
BMJ Open QualityObjective The aim of this study is to identify the key barriers that prevent medication administration errors (MAEs) from being reported by nurses in Lebanese hospitals.Methods A quantitative cross-sectional study was conducted at Hotel-Dieu de France ...
Remy Daou +3 more
doaj +1 more source
Improvement of medication error reporting: An applied motivation program in pediatric units.
J Educ Health Promot, 2021 Massah L, Mohammadi R, Namnabati M.
europepmc +1 more source
What You Need to Know about Bar-Code Medication Administration [PDF]
, 2019 Medication errors are the most common type of preventable error. Bar-code medication administration (BCMA) technology was designed to reduce medication administration errors.
Kuhlmann, Martha, DNP, MSN, RN, FNP, PMHCNS-BC, APRN +2 more
core +1 more source