Results 91 to 100 of about 370,533 (353)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Strategies to reduce medication errors with reference to older adults [PDF]

, 2006
Background  In Australia, around 59% of the general population uses prescription medication with this number increasing to about 86% in those aged 65 and over and 83% of the population over 85 using two or more medications simultaneously. A recent report
Adams C, Aufseeser Weiss MR, Australian Council for Safety and Quality in Health Care., Australian Institute of Health and Welfare (AIHW)., Australian Institute of Health and Welfare., Ayuthya S, Bates DW, Bayne T, Bolton P, Boyle CM, Brent Hodgkinson, Briggs B, Brown HN, Brown SJ, Burton ME, Casner PR, Cerne F, Hawkey CJ, Heinemann D, Hurley SF, Khan KS, Kim Nichols, Kruse H, Larrabee JH, Leape LL, Lengacher CA, Ludwig Beymer P, McNally KM, Mungall DR, Mutter M, Nelson R, NHMRC., Overhage JM, Papastrat K, Pape TM, Ray MD, Rhonda Nay, Roark DC, Roughead EE, Schaubhut RM, Shah NR, Shojania KG, Spencer DC, Strohecker S, Susan Koch, Westwood M, White RH   +46 more
core   +1 more source

Medication errors: classification of seriousness, type, and of medications involved in the reports from a university teaching hospital

Brazilian Journal of Pharmaceutical Sciences, 2013
Medication errors can be frequent in hospitals; these errors are multidisciplinary and occur at various stages of the drug therapy. The present study evaluated the seriousness, the type and the drugs involved in medication errors reported at the Hospital
Gabriella Rejane dos Santos Dalmolin, Eloni Terezinha Rotta, José Roberto Goldim   +2 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Nurse interrupted: Development of a realistic medication administration simulation for undergraduate nurses [PDF]

, 2015
© 2015 Elsevier Ltd. Background: Medication errors are a global phenomenon. Each year Australia-wide there are up to 96,000 preventable medication errors and in the United States there are approximately 450,000 preventable medication errors.
Daly, J, Davidson, PM, Hayes, C, Jackson, D, Power, T   +4 more
core   +1 more source

Evaluation of Medication Errors in Hospitalized Patients

مجله كليه طب الكندي, 2012
Objectives: Many medication errors occur in the hospital, and these can endanger patients. The purpose of this study was to evaluate the incidence of medication errors in hospitalized patients, and to categorize the most frequent types of errors, and to
Hamoudi A. Mosah,, Ahmed S. Sahib,, Haedar A. AL-Biati   +2 more
doaj  

A Model for Monitoring Spontaneously Reported Medication Errors Using the Adjuvanted Recombinant Zoster Vaccine as an Example

Advances in Pharmacological and Pharmaceutical Sciences
A European legislation was put in place for the reporting of medication errors, and guidelines were drafted to help stakeholders in the reporting, evaluation, and, ultimately, minimization of these errors. As part of pharmacovigilance reporting, a proper
Christophe Dessart, Fernanda Tavares-Da-Silva, Lionel Van Holle, Olivia Mahaux, Jens-Ulrich Stegmann   +4 more
doaj   +1 more source

Risk Factors, Causes, and Strategies for Reducing Medication Errors: A Narrative Review

مجلة علوم ذي قار
— Medication errors, which refer to any deviation from the prescribed medication regimen, can have seriously affected patient safety and treatment outcomes. It underscores the need for healthcare professionals to follow medication orders precisely and to
Suha Nadem, Makarim M. Ali Hassan, Amena Lafeta Muttlaq Al-Shareefi   +2 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Electronic Prescription and Medication Errors

مدیریت اطلاعات سلامت, 2015
On one hand, drug therapy is one of the most powerful tools for the treatment of diseases, and on the other hand, one of the most common medical errors is related to hand written prescription. Patient safety is endangered due to illegible of hand written
Ebtesam Savari, Sima Ajami
doaj